Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells

Joon Young Bae; Jin Woo Lee; Qinghao Jin; Hari Jang; Dongho Lee; Youngsoo Kim; Jin Tae Hong; Mi Kyeong Lee; Moon Soon Lee; Bang Yeon Hwang

doi:10.1002/cbdv.201600243

Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells

Joon Young Bae, Jin Woo Lee, Qinghao Jin, Hari Jang, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Moon Soon Lee, Bang Yeon Hwang

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Bioassay-guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C-methylated flavan-3-ols, bletillanols A (1) and B (2), along with ten known compounds (3 – 12). Their structures were determined by using extensive spectroscopic analysis including 1D-, 2D-NMR, and circular dichroism data. All of the isolated compounds were tested for their inhibitory potential on the nitric oxide generation in LPS-stimulated RAW 264.7 cells.

Original language	English
Article number	e1600243
Journal	Chemistry and Biodiversity
Volume	14
Issue number	2
DOIs	https://doi.org/10.1002/cbdv.201600243
Publication status	Published - 2017 Feb 1

Bibliographical note

Publisher Copyright:
© 2017 Wiley-VHCA AG, Zurich, Switzerland

Keywords

Bletilla striata
Bletillanol A
Bletillanol B
Flavan-3-ol
Nitric oxide production
Orchidaceae

ASJC Scopus subject areas

Bioengineering
Biochemistry
General Chemistry
Molecular Medicine
Molecular Biology

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10.1002/cbdv.201600243

Cite this

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abstract = "Bioassay-guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C-methylated flavan-3-ols, bletillanols A (1) and B (2), along with ten known compounds (3 – 12). Their structures were determined by using extensive spectroscopic analysis including 1D-, 2D-NMR, and circular dichroism data. All of the isolated compounds were tested for their inhibitory potential on the nitric oxide generation in LPS-stimulated RAW 264.7 cells.",

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AU - Lee, Jin Woo

AU - Jin, Qinghao

AU - Jang, Hari

AU - Lee, Dongho

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Lee, Moon Soon

AU - Hwang, Bang Yeon

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AB - Bioassay-guided fractionation of the MeOH extract of the tubers of Bletilla striata led to the isolation of two new C-methylated flavan-3-ols, bletillanols A (1) and B (2), along with ten known compounds (3 – 12). Their structures were determined by using extensive spectroscopic analysis including 1D-, 2D-NMR, and circular dichroism data. All of the isolated compounds were tested for their inhibitory potential on the nitric oxide generation in LPS-stimulated RAW 264.7 cells.

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KW - Bletillanol B

KW - Flavan-3-ol

KW - Nitric oxide production

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Chemical Constituents Isolated from Bletilla striata and Their Inhibitory Effects on Nitric Oxide Production in RAW 264.7 Cells

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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