Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro

Seung Hyun Kim; Sin Duk Jang; Ki Yong Lee; Sang Hyun Sung; Young Choong Kim

doi:10.1080/14756360802051362

Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro

Seung Hyun Kim
, Sin Duk Jang
, Ki Yong Lee
, Sang Hyun Sung
, Young Choong Kim^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-β-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 μM.

Original language	English
Pages (from-to)	230-233
Number of pages	4
Journal	Journal of Enzyme Inhibition and Medicinal Chemistry
Volume	24
Issue number	1
DOIs	https://doi.org/10.1080/14756360802051362
Publication status	Published - 2009
Externally published	Yes

Keywords

BV2 microglia
Inhibition
Lipopolysaccharide
Nitric oxide
Polygala japonica

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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10.1080/14756360802051362

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title = "Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro",

abstract = "A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-β-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 μM.",

keywords = "BV2 microglia, Inhibition, Lipopolysaccharide, Nitric oxide, Polygala japonica",

author = "Kim, \{Seung Hyun\} and Jang, \{Sin Duk\} and Lee, \{Ki Yong\} and Sung, \{Sang Hyun\} and Kim, \{Young Choong\}",

year = "2009",

doi = "10.1080/14756360802051362",

language = "English",

volume = "24",

pages = "230--233",

journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",

issn = "1475-6366",

publisher = "Taylor and Francis Ltd.",

number = "1",

}

TY - JOUR

T1 - Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro

AU - Kim, Seung Hyun

AU - Jang, Sin Duk

AU - Lee, Ki Yong

AU - Sung, Sang Hyun

AU - Kim, Young Choong

PY - 2009

Y1 - 2009

N2 - A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-β-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 μM.

AB - A methanolic extract of dried leaves of Polygala japonica Houtt (Polygalaceae) significantly attenuated nitric oxide production in lipopolysaccharide-simulated BV2 microglia. Five anthraquinones chrysophanol (1), emodin (2), aloe-emodin (3), emodin 8-O-β-D-glucopyranoside (4) and trihydroxy anthraquinone (5), and four flavonoids kaempferol (6), chrysoeriol (7), kaempferol 3-gentiobioside (8) and isorhamnetin (9) were isolated from the methanolic extract using bioactivity-guided fractionation. Among them, compounds 1-4, 6 and 7 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at the concentrations ranging from 1.0 to 100.0 μM.

KW - BV2 microglia

KW - Inhibition

KW - Lipopolysaccharide

KW - Nitric oxide

KW - Polygala japonica

UR - https://www.scopus.com/pages/publications/58949092758

U2 - 10.1080/14756360802051362

DO - 10.1080/14756360802051362

M3 - Article

C2 - 18825536

AN - SCOPUS:58949092758

SN - 1475-6366

VL - 24

SP - 230

EP - 233

JO - Journal of Enzyme Inhibition and Medicinal Chemistry

JF - Journal of Enzyme Inhibition and Medicinal Chemistry

IS - 1

ER -

Chemical constituents isolated from Polygala japonica leaves and their inhibitory effect on nitric oxide production in vitro

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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