Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Jaeyoung Kwon; Sunita Basnet; Jin Woo Lee; Eun Kyoung Seo; Nanzad Tsevegsuren; Bang Yeon Hwang; Dongho Lee

doi:10.1016/j.bmcl.2015.05.062

Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Jaeyoung Kwon, Sunita Basnet, Jin Woo Lee, Eun Kyoung Seo, Nanzad Tsevegsuren, Bang Yeon Hwang, Dongho Lee

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Abstract Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells.

Original language	English
Article number	22752
Pages (from-to)	3314-3318
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	25
Issue number	16
DOIs	https://doi.org/10.1016/j.bmcl.2015.05.062
Publication status	Published - 2015 Jul 3

Keywords

Flavonostilbenes
Nitric oxide production inhibitor
Sophora alopecuroides L.

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2015.05.062

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Kwon, J., Basnet, S., Lee, J. W., Seo, E. K., Tsevegsuren, N., Hwang, B. Y., & Lee, D. (2015). Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. Bioorganic and Medicinal Chemistry Letters, 25(16), 3314-3318. [22752]. https://doi.org/10.1016/j.bmcl.2015.05.062

Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages. / Kwon, Jaeyoung; Basnet, Sunita; Lee, Jin Woo et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 25, No. 16, 22752, 03.07.2015, p. 3314-3318.

Research output: Contribution to journal › Article › peer-review

Kwon, J, Basnet, S, Lee, JW, Seo, EK, Tsevegsuren, N, Hwang, BY & Lee, D 2015, 'Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages', Bioorganic and Medicinal Chemistry Letters, vol. 25, no. 16, 22752, pp. 3314-3318. https://doi.org/10.1016/j.bmcl.2015.05.062

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title = "Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages",

abstract = "Abstract Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells.",

keywords = "Flavonostilbenes, Nitric oxide production inhibitor, Sophora alopecuroides L.",

author = "Jaeyoung Kwon and Sunita Basnet and Lee, {Jin Woo} and Seo, {Eun Kyoung} and Nanzad Tsevegsuren and Hwang, {Bang Yeon} and Dongho Lee",

note = "Funding Information: This research was supported by a Grant from the Korea Polar Research Institute ( PM13030 ) and Mongolian Foundation for Science and Technology (N.Ts). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

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doi = "10.1016/j.bmcl.2015.05.062",

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AU - Basnet, Sunita

AU - Lee, Jin Woo

AU - Seo, Eun Kyoung

AU - Tsevegsuren, Nanzad

AU - Hwang, Bang Yeon

AU - Lee, Dongho

N1 - Funding Information: This research was supported by a Grant from the Korea Polar Research Institute ( PM13030 ) and Mongolian Foundation for Science and Technology (N.Ts). Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/7/3

Y1 - 2015/7/3

N2 - Abstract Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells.

AB - Abstract Three new flavonostilbenes, alopecurones M-O (1-3), were isolated from the root bark of Sophora alopecuroides L. together with 21 known compounds. The structures of the isolated compounds were elucidated by using NMR, MS, and CD spectroscopic data. All isolates were evaluated for their potential to inhibit LPS-induced nitric oxide production in RAW 264.7 cells.

KW - Flavonostilbenes

KW - Nitric oxide production inhibitor

KW - Sophora alopecuroides L.

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Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages

Abstract

Keywords

ASJC Scopus subject areas

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