Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects

Jaeyoung Kwon; Nguyen Tuan Hiep; Dong Woo Kim; Sungeun Hong; Yuanqiang Guo; Bang Yeon Hwang; Hak Ju Lee; Woongchon Mar; Dongho Lee

doi:10.1021/acs.jnatprod.6b00204

Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects

Jaeyoung Kwon
, Nguyen Tuan Hiep
, Dong Woo Kim
, Sungeun Hong
, Yuanqiang Guo
, Bang Yeon Hwang
, Hak Ju Lee
, Woongchon Mar^*
, Dongho Lee

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Seventy-five compounds, including 21 new compounds (1-21), were isolated from the root bark of Cudrania tricuspidata. The structures of the isolated compounds were elucidated by interpretation of their spectroscopic data. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death, and nine compounds had activities with EC₅₀ values of 1.9-30.2 μM. The 75 isolated compounds along with 34 previously reported xanthones were tested also for neuroprotective effects against the 1-methyl-4-phenylpyridinium ion (MPP⁺) and oxygen glucose deprivation (OGD)-induced cell death. Three compounds were active against MPP⁺-induced cell death with EC₅₀ values of 0.2-10.3 μM, and 23 compounds were active in the OGD model with EC₅₀ values of 2.9-35.5 μM.

Original language	English
Pages (from-to)	1938-1951
Number of pages	14
Journal	Journal of Natural Products
Volume	79
Issue number	8
DOIs	https://doi.org/10.1021/acs.jnatprod.6b00204
Publication status	Published - 2016 Aug 26

Bibliographical note

Funding Information:
This research was supported by a grant from the National Research Foundation of Kor ea ( N R F - 2015R1D1A1A01060321), BK21 Plus program in 2015 through NRF funded by the Ministry of Education of Korea, and the Institute of Life Science and Natural Resources, Korea University.

Publisher Copyright:
© 2016 The American Chemical Society and American Society of Pharmacognosy.

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.6b00204

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title = "Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects",

abstract = "Seventy-five compounds, including 21 new compounds (1-21), were isolated from the root bark of Cudrania tricuspidata. The structures of the isolated compounds were elucidated by interpretation of their spectroscopic data. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death, and nine compounds had activities with EC50 values of 1.9-30.2 μM. The 75 isolated compounds along with 34 previously reported xanthones were tested also for neuroprotective effects against the 1-methyl-4-phenylpyridinium ion (MPP+) and oxygen glucose deprivation (OGD)-induced cell death. Three compounds were active against MPP+-induced cell death with EC50 values of 0.2-10.3 μM, and 23 compounds were active in the OGD model with EC50 values of 2.9-35.5 μM.",

author = "Jaeyoung Kwon and Hiep, \{Nguyen Tuan\} and Kim, \{Dong Woo\} and Sungeun Hong and Yuanqiang Guo and Hwang, \{Bang Yeon\} and Lee, \{Hak Ju\} and Woongchon Mar and Dongho Lee",

note = "Funding Information: This research was supported by a grant from the National Research Foundation of Kor ea ( N R F - 2015R1D1A1A01060321), BK21 Plus program in 2015 through NRF funded by the Ministry of Education of Korea, and the Institute of Life Science and Natural Resources, Korea University. Publisher Copyright: {\textcopyright} 2016 The American Chemical Society and American Society of Pharmacognosy.",

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month = aug,

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doi = "10.1021/acs.jnatprod.6b00204",

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AU - Kwon, Jaeyoung

AU - Hiep, Nguyen Tuan

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AU - Hong, Sungeun

AU - Guo, Yuanqiang

AU - Hwang, Bang Yeon

AU - Lee, Hak Ju

AU - Mar, Woongchon

AU - Lee, Dongho

N1 - Funding Information: This research was supported by a grant from the National Research Foundation of Kor ea ( N R F - 2015R1D1A1A01060321), BK21 Plus program in 2015 through NRF funded by the Ministry of Education of Korea, and the Institute of Life Science and Natural Resources, Korea University. Publisher Copyright: © 2016 The American Chemical Society and American Society of Pharmacognosy.

PY - 2016/8/26

Y1 - 2016/8/26

N2 - Seventy-five compounds, including 21 new compounds (1-21), were isolated from the root bark of Cudrania tricuspidata. The structures of the isolated compounds were elucidated by interpretation of their spectroscopic data. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death, and nine compounds had activities with EC50 values of 1.9-30.2 μM. The 75 isolated compounds along with 34 previously reported xanthones were tested also for neuroprotective effects against the 1-methyl-4-phenylpyridinium ion (MPP+) and oxygen glucose deprivation (OGD)-induced cell death. Three compounds were active against MPP+-induced cell death with EC50 values of 0.2-10.3 μM, and 23 compounds were active in the OGD model with EC50 values of 2.9-35.5 μM.

AB - Seventy-five compounds, including 21 new compounds (1-21), were isolated from the root bark of Cudrania tricuspidata. The structures of the isolated compounds were elucidated by interpretation of their spectroscopic data. All isolated compounds were evaluated for their neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cell death, and nine compounds had activities with EC50 values of 1.9-30.2 μM. The 75 isolated compounds along with 34 previously reported xanthones were tested also for neuroprotective effects against the 1-methyl-4-phenylpyridinium ion (MPP+) and oxygen glucose deprivation (OGD)-induced cell death. Three compounds were active against MPP+-induced cell death with EC50 values of 0.2-10.3 μM, and 23 compounds were active in the OGD model with EC50 values of 2.9-35.5 μM.

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JF - Journal of Natural Products

IS - 8

ER -

Chemical Constituents Isolated from the Root Bark of Cudrania tricuspidata and Their Potential Neuroprotective Effects

Abstract

Bibliographical note

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