Chemical Probes and Activity‐Based Protein Profiling for Cancer Research

Mohammad Faysal Al Mazid; Seung Bin Park; Subba Rao Cheekatla; Dhiraj P. Murale; Kyung Ho Shin; Jun Seok Lee

doi:10.3390/ijms23115936

Chemical Probes and Activity‐Based Protein Profiling for Cancer Research

Mohammad Faysal Al Mazid, Seung Bin Park, Subba Rao Cheekatla, Dhiraj P. Murale, Kyung Ho Shin, Jun Seok Lee

Research output: Contribution to journal › Review article › peer-review

5 Citations (Scopus)

Abstract

Chemical probes can be used to understand the complex biological nature of diseases. Due to the diversity of cancer types and dynamic regulatory pathways involved in the disease, there is a need to identify signaling pathways and associated proteins or enzymes that are traceable or detectable in tests for cancer diagnosis and treatment. Currently, fluorogenic chemical probes are widely used to detect cancer‐associated proteins and their binding partners. These probes are also applicable in photodynamic therapy to determine drug efficacy and monitor regulating factors. In this review, we discuss the synthesis of chemical probes for different cancer types from 2016 to the present time and their application in monitoring the activity of transferases, hydrolases, deacetylases, oxidoreductases, and immune cells. Moreover, we elaborate on their potential roles in photodynamic therapy.

Original language	English
Article number	5936
Journal	International journal of molecular sciences
Volume	23
Issue number	11
DOIs	https://doi.org/10.3390/ijms23115936
Publication status	Published - 2022 Jun 1

Bibliographical note

Funding Information:
Funding: This work was supported by the National Research Foundation funded by the Ministry of Science, ICT, and Future Planning (NRF‐2018M3A9H4079286, NRF‐2020R1A2C2004422, and NRF‐2021H1D3A2A02080762).

Publisher Copyright:
© 2022 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

activity‐based probe
near‐infrared probe
photodynamic therapy

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms23115936

Cite this

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title = "Chemical Probes and Activity‐Based Protein Profiling for Cancer Research",

abstract = "Chemical probes can be used to understand the complex biological nature of diseases. Due to the diversity of cancer types and dynamic regulatory pathways involved in the disease, there is a need to identify signaling pathways and associated proteins or enzymes that are traceable or detectable in tests for cancer diagnosis and treatment. Currently, fluorogenic chemical probes are widely used to detect cancer‐associated proteins and their binding partners. These probes are also applicable in photodynamic therapy to determine drug efficacy and monitor regulating factors. In this review, we discuss the synthesis of chemical probes for different cancer types from 2016 to the present time and their application in monitoring the activity of transferases, hydrolases, deacetylases, oxidoreductases, and immune cells. Moreover, we elaborate on their potential roles in photodynamic therapy.",

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note = "Funding Information: Funding: This work was supported by the National Research Foundation funded by the Ministry of Science, ICT, and Future Planning (NRF‐2018M3A9H4079286, NRF‐2020R1A2C2004422, and NRF‐2021H1D3A2A02080762). Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

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AU - Al Mazid, Mohammad Faysal

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AU - Cheekatla, Subba Rao

AU - Murale, Dhiraj P.

AU - Shin, Kyung Ho

AU - Lee, Jun Seok

N1 - Funding Information: Funding: This work was supported by the National Research Foundation funded by the Ministry of Science, ICT, and Future Planning (NRF‐2018M3A9H4079286, NRF‐2020R1A2C2004422, and NRF‐2021H1D3A2A02080762). Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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N2 - Chemical probes can be used to understand the complex biological nature of diseases. Due to the diversity of cancer types and dynamic regulatory pathways involved in the disease, there is a need to identify signaling pathways and associated proteins or enzymes that are traceable or detectable in tests for cancer diagnosis and treatment. Currently, fluorogenic chemical probes are widely used to detect cancer‐associated proteins and their binding partners. These probes are also applicable in photodynamic therapy to determine drug efficacy and monitor regulating factors. In this review, we discuss the synthesis of chemical probes for different cancer types from 2016 to the present time and their application in monitoring the activity of transferases, hydrolases, deacetylases, oxidoreductases, and immune cells. Moreover, we elaborate on their potential roles in photodynamic therapy.

AB - Chemical probes can be used to understand the complex biological nature of diseases. Due to the diversity of cancer types and dynamic regulatory pathways involved in the disease, there is a need to identify signaling pathways and associated proteins or enzymes that are traceable or detectable in tests for cancer diagnosis and treatment. Currently, fluorogenic chemical probes are widely used to detect cancer‐associated proteins and their binding partners. These probes are also applicable in photodynamic therapy to determine drug efficacy and monitor regulating factors. In this review, we discuss the synthesis of chemical probes for different cancer types from 2016 to the present time and their application in monitoring the activity of transferases, hydrolases, deacetylases, oxidoreductases, and immune cells. Moreover, we elaborate on their potential roles in photodynamic therapy.

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Chemical Probes and Activity‐Based Protein Profiling for Cancer Research

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this