Chemistry of Cyanide Adducts of Aldimines from Aniline Derivatives

Eunjoon Park, Jiye Jeon, Cheol Hong Cheon

Research output: Contribution to journalReview articlepeer-review

15 Citations (Scopus)


The chemistry of hydrogen cyanide adducts of imines is well-developed, but that of cyanide adducts remains unexplored. This is presumably because these cyanide adducts are not stable and thus not readily available in their isolated forms. In this personal account, we present the progress made in our research program towards the development of novel organic transformations utilizing cyanide adducts of imines as key intermediates. We also report the application of these methodologies to the total synthesis of natural products including indole alkaloids.

Original languageEnglish
Pages (from-to)1474-1488
Number of pages15
JournalChemical Record
Issue number10
Publication statusPublished - 2018 Oct

Bibliographical note

Funding Information:
This work was financially supported by the National Research Foundation of Korea (NRF), funded by the Korean Government (NRF-20100020209 and NRF-2015R1D1A1A01057200). C.-H.C. is grateful for financial support from an NRF grant funded by the Korean Government (NRF-2014-011165, Center for New Directions in Organic Synthesis).

Publisher Copyright:
© 2018 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim


  • Aerobic Oxidation
  • Aldimines
  • Cyanide
  • Imino-Stetter Reaction
  • Indole-3-acetic Acids

ASJC Scopus subject areas

  • General Chemistry
  • Biochemistry
  • General Chemical Engineering
  • Materials Chemistry


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