The chemistry of hydrogen cyanide adducts of imines is well-developed, but that of cyanide adducts remains unexplored. This is presumably because these cyanide adducts are not stable and thus not readily available in their isolated forms. In this personal account, we present the progress made in our research program towards the development of novel organic transformations utilizing cyanide adducts of imines as key intermediates. We also report the application of these methodologies to the total synthesis of natural products including indole alkaloids.
Bibliographical noteFunding Information:
This work was financially supported by the National Research Foundation of Korea (NRF), funded by the Korean Government (NRF-20100020209 and NRF-2015R1D1A1A01057200). C.-H.C. is grateful for financial support from an NRF grant funded by the Korean Government (NRF-2014-011165, Center for New Directions in Organic Synthesis).
© 2018 The Chemical Society of Japan & Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- Aerobic Oxidation
- Imino-Stetter Reaction
- Indole-3-acetic Acids
ASJC Scopus subject areas
- Chemical Engineering(all)
- Materials Chemistry