Chitosan and its derivatives for tissue engineering applications

In Yong Kim, Seog Jin Seo, Hyun Seuk Moon, Mi Kyong Yoo, In Young Park, Bom Chol Kim, Chong Su Cho

Research output: Contribution to journalReview articlepeer-review

1250 Citations (Scopus)


Tissue engineering is an important therapeutic strategy for present and future medicine. Recently, functional biomaterial researches have been directed towards the development of improved scaffolds for regenerative medicine. Chitosan is a natural polymer from renewable resources, obtained from shell of shellfish, and the wastes of the seafood industry. It has novel properties such as biocompatibility, biodegradability, antibacterial, and wound-healing activity. Furthermore, recent studies suggested that chitosan and its derivatives are promising candidates as a supporting material for tissue engineering applications owing to their porous structure, gel forming properties, ease of chemical modification, high affinity to in vivo macromolecules, and so on. In this review, we focus on the various types of chitosan derivatives and their use in various tissue engineering applications namely, skin, bone, cartilage, liver, nerve and blood vessel.

Original languageEnglish
Pages (from-to)1-21
Number of pages21
JournalBiotechnology Advances
Issue number1
Publication statusPublished - 2008 Jan

Bibliographical note

Funding Information:
This review was supported by a grant (B-2005-10) from Marine Bioprocess Research Center of the Marine Bio 21 Center funded by the Ministry of Maritime Affairs & Fisheries, Republic of Korea. I. Y. Kim was supported by Brain Korea 21 program.


  • Chitin
  • Chitosan
  • Chitosan derivatives
  • Scaffold
  • Tissue engineering

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology


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