Choice between levofloxacin and moxifloxacin and multidrug-resistant tuberculosis treatment outcomes

Young Ae Kang; Tae Sun Shim; Won Jung Koh; Seung Heon Lee; Chang Hoon Lee; Jae Chol Choi; Jae Ho Lee; Seung Hun Jang; Kwang Ha Yoo; Ki Hwan Jung; Ki Uk Kim; Sang Bong Choi; Yon Ju Ryu; Kyung Chan Kim; Soojung Um; Yong Soo Kwon; Yee Hyung Kim; Won Il Choi; Kyeongman Jeon; Yong Il Hwang; Se Joong Kim; Hyun Kyung Lee; Eunyoung Heo; Jae Joon Yim

doi:10.1513/AnnalsATS.201510-690BC

Choice between levofloxacin and moxifloxacin and multidrug-resistant tuberculosis treatment outcomes

Young Ae Kang, Tae Sun Shim, Won Jung Koh, Seung Heon Lee, Chang Hoon Lee, Jae Chol Choi, Jae Ho Lee, Seung Hun Jang, Kwang Ha Yoo, Ki Hwan Jung, Ki Uk Kim, Sang Bong Choi, Yon Ju Ryu, Kyung Chan Kim, Soojung Um, Yong Soo Kwon, Yee Hyung Kim, Won Il Choi, Kyeongman Jeon, Yong Il HwangSe Joong Kim, Hyun Kyung Lee, Eunyoung Heo, Jae Joon Yim

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

Rationale: We previously showed that the choice of levofloxacin or moxifloxacin for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-TB) did not affect sputumculture conversion at 3 months of treatment. Objectives: To compare final treatment outcomes between patients with MDR-TB randomized to levofloxacin or moxifloxacin. Methods: A total of 151 participants with MDR-TB who were included for the final analysis in our previous trial were followed through the end of treatment. Treatment outcomes were compared between 77 patients in the levofloxacin group and 74 in the moxifloxacin group, based on the 2008 World Health Organization definitions as well as 2013 revised definitions of treatment outcomes. In addition, the time to culture conversion was compared between the two groups. Measurements and Main Results: Treatment outcomes were not different between the two groups, based on 2008 World Health Organization definitions as well as 2013 definitions. With 2008 definitions, cure was achieved in 54 patients (70.1%) in the levofloxacin group and 54 (73.0%) in the moxifloxacin group (P = 0.72). Treatment success rates, including cure and treatment completed, were not different between the two groups (87.0 vs. 81.1%, P = 0.38). With 2013 definitions, cure rates (83.1 vs. 78.4%, P = 0.54) and treatment success rates (84.4 vs. 79.7%, P = 0.53) were also similar between the levofloxacin and moxifloxacin groups. Time to culture conversion was also not different between the two groups (27.0 vs. 45.0 d, P = 0.11 on liquid media; 17.0 vs. 42.0 d, P = 0.14 on solid media). Patients in the levofloxacin group had more adverse events than those in the moxifloxacin group (79.2 vs. 63.5%, P = 0.03), especially musculoskeletal ones (37.7 vs. 14.9%, P = 0.001). Conclusions: The choice of levofloxacin or moxifloxacin made no difference to the final treatment outcome among patients with fluoroquinolone-sensitiveMDR-TB.

Original language	English
Pages (from-to)	364-370
Number of pages	7
Journal	Annals of the American Thoracic Society
Volume	13
Issue number	3
DOIs	https://doi.org/10.1513/AnnalsATS.201510-690BC
Publication status	Published - 2016 Mar
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2016 by the American Thoracic Society.

Keywords

Fluoroquinolones
Levofloxacin
Moxifloxacin
Multidrug-resistant tuberculosis

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1513/AnnalsATS.201510-690BC

Cite this

Kang, Y. A., Shim, T. S., Koh, W. J., Lee, S. H., Lee, C. H., Choi, J. C., Lee, J. H., Jang, S. H., Yoo, K. H., Jung, K. H., Kim, K. U., Choi, S. B., Ryu, Y. J., Kim, K. C., Um, S., Kwon, Y. S., Kim, Y. H., Choi, W. I., Jeon, K., ... Yim, J. J. (2016). Choice between levofloxacin and moxifloxacin and multidrug-resistant tuberculosis treatment outcomes. Annals of the American Thoracic Society, 13(3), 364-370. https://doi.org/10.1513/AnnalsATS.201510-690BC

Kang, YA, Shim, TS, Koh, WJ, Lee, SH, Lee, CH, Choi, JC, Lee, JH, Jang, SH, Yoo, KH, Jung, KH, Kim, KU, Choi, SB, Ryu, YJ, Kim, KC, Um, S, Kwon, YS, Kim, YH, Choi, WI, Jeon, K, Hwang, YI, Kim, SJ, Lee, HK, Heo, E & Yim, JJ 2016, 'Choice between levofloxacin and moxifloxacin and multidrug-resistant tuberculosis treatment outcomes', Annals of the American Thoracic Society, vol. 13, no. 3, pp. 364-370. https://doi.org/10.1513/AnnalsATS.201510-690BC

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title = "Choice between levofloxacin and moxifloxacin and multidrug-resistant tuberculosis treatment outcomes",

abstract = "Rationale: We previously showed that the choice of levofloxacin or moxifloxacin for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-TB) did not affect sputumculture conversion at 3 months of treatment. Objectives: To compare final treatment outcomes between patients with MDR-TB randomized to levofloxacin or moxifloxacin. Methods: A total of 151 participants with MDR-TB who were included for the final analysis in our previous trial were followed through the end of treatment. Treatment outcomes were compared between 77 patients in the levofloxacin group and 74 in the moxifloxacin group, based on the 2008 World Health Organization definitions as well as 2013 revised definitions of treatment outcomes. In addition, the time to culture conversion was compared between the two groups. Measurements and Main Results: Treatment outcomes were not different between the two groups, based on 2008 World Health Organization definitions as well as 2013 definitions. With 2008 definitions, cure was achieved in 54 patients (70.1%) in the levofloxacin group and 54 (73.0%) in the moxifloxacin group (P = 0.72). Treatment success rates, including cure and treatment completed, were not different between the two groups (87.0 vs. 81.1%, P = 0.38). With 2013 definitions, cure rates (83.1 vs. 78.4%, P = 0.54) and treatment success rates (84.4 vs. 79.7%, P = 0.53) were also similar between the levofloxacin and moxifloxacin groups. Time to culture conversion was also not different between the two groups (27.0 vs. 45.0 d, P = 0.11 on liquid media; 17.0 vs. 42.0 d, P = 0.14 on solid media). Patients in the levofloxacin group had more adverse events than those in the moxifloxacin group (79.2 vs. 63.5%, P = 0.03), especially musculoskeletal ones (37.7 vs. 14.9%, P = 0.001). Conclusions: The choice of levofloxacin or moxifloxacin made no difference to the final treatment outcome among patients with fluoroquinolone-sensitiveMDR-TB.",

keywords = "Fluoroquinolones, Levofloxacin, Moxifloxacin, Multidrug-resistant tuberculosis",

author = "Kang, {Young Ae} and Shim, {Tae Sun} and Koh, {Won Jung} and Lee, {Seung Heon} and Lee, {Chang Hoon} and Choi, {Jae Chol} and Lee, {Jae Ho} and Jang, {Seung Hun} and Yoo, {Kwang Ha} and Jung, {Ki Hwan} and Kim, {Ki Uk} and Choi, {Sang Bong} and Ryu, {Yon Ju} and Kim, {Kyung Chan} and Soojung Um and Kwon, {Yong Soo} and Kim, {Yee Hyung} and Choi, {Won Il} and Kyeongman Jeon and Hwang, {Yong Il} and Kim, {Se Joong} and Lee, {Hyun Kyung} and Eunyoung Heo and Yim, {Jae Joon}",

note = "Publisher Copyright: Copyright {\textcopyright} 2016 by the American Thoracic Society.",

year = "2016",

month = mar,

doi = "10.1513/AnnalsATS.201510-690BC",

language = "English",

volume = "13",

pages = "364--370",

journal = "Annals of the American Thoracic Society",

issn = "2325-6621",

publisher = "American Thoracic Society",

number = "3",

}

TY - JOUR

T1 - Choice between levofloxacin and moxifloxacin and multidrug-resistant tuberculosis treatment outcomes

AU - Kang, Young Ae

AU - Shim, Tae Sun

AU - Koh, Won Jung

AU - Lee, Seung Heon

AU - Lee, Chang Hoon

AU - Choi, Jae Chol

AU - Lee, Jae Ho

AU - Jang, Seung Hun

AU - Yoo, Kwang Ha

AU - Jung, Ki Hwan

AU - Kim, Ki Uk

AU - Choi, Sang Bong

AU - Ryu, Yon Ju

AU - Kim, Kyung Chan

AU - Um, Soojung

AU - Kwon, Yong Soo

AU - Kim, Yee Hyung

AU - Choi, Won Il

AU - Jeon, Kyeongman

AU - Hwang, Yong Il

AU - Kim, Se Joong

AU - Lee, Hyun Kyung

AU - Heo, Eunyoung

AU - Yim, Jae Joon

PY - 2016/3

Y1 - 2016/3

N2 - Rationale: We previously showed that the choice of levofloxacin or moxifloxacin for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-TB) did not affect sputumculture conversion at 3 months of treatment. Objectives: To compare final treatment outcomes between patients with MDR-TB randomized to levofloxacin or moxifloxacin. Methods: A total of 151 participants with MDR-TB who were included for the final analysis in our previous trial were followed through the end of treatment. Treatment outcomes were compared between 77 patients in the levofloxacin group and 74 in the moxifloxacin group, based on the 2008 World Health Organization definitions as well as 2013 revised definitions of treatment outcomes. In addition, the time to culture conversion was compared between the two groups. Measurements and Main Results: Treatment outcomes were not different between the two groups, based on 2008 World Health Organization definitions as well as 2013 definitions. With 2008 definitions, cure was achieved in 54 patients (70.1%) in the levofloxacin group and 54 (73.0%) in the moxifloxacin group (P = 0.72). Treatment success rates, including cure and treatment completed, were not different between the two groups (87.0 vs. 81.1%, P = 0.38). With 2013 definitions, cure rates (83.1 vs. 78.4%, P = 0.54) and treatment success rates (84.4 vs. 79.7%, P = 0.53) were also similar between the levofloxacin and moxifloxacin groups. Time to culture conversion was also not different between the two groups (27.0 vs. 45.0 d, P = 0.11 on liquid media; 17.0 vs. 42.0 d, P = 0.14 on solid media). Patients in the levofloxacin group had more adverse events than those in the moxifloxacin group (79.2 vs. 63.5%, P = 0.03), especially musculoskeletal ones (37.7 vs. 14.9%, P = 0.001). Conclusions: The choice of levofloxacin or moxifloxacin made no difference to the final treatment outcome among patients with fluoroquinolone-sensitiveMDR-TB.

AB - Rationale: We previously showed that the choice of levofloxacin or moxifloxacin for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-TB) did not affect sputumculture conversion at 3 months of treatment. Objectives: To compare final treatment outcomes between patients with MDR-TB randomized to levofloxacin or moxifloxacin. Methods: A total of 151 participants with MDR-TB who were included for the final analysis in our previous trial were followed through the end of treatment. Treatment outcomes were compared between 77 patients in the levofloxacin group and 74 in the moxifloxacin group, based on the 2008 World Health Organization definitions as well as 2013 revised definitions of treatment outcomes. In addition, the time to culture conversion was compared between the two groups. Measurements and Main Results: Treatment outcomes were not different between the two groups, based on 2008 World Health Organization definitions as well as 2013 definitions. With 2008 definitions, cure was achieved in 54 patients (70.1%) in the levofloxacin group and 54 (73.0%) in the moxifloxacin group (P = 0.72). Treatment success rates, including cure and treatment completed, were not different between the two groups (87.0 vs. 81.1%, P = 0.38). With 2013 definitions, cure rates (83.1 vs. 78.4%, P = 0.54) and treatment success rates (84.4 vs. 79.7%, P = 0.53) were also similar between the levofloxacin and moxifloxacin groups. Time to culture conversion was also not different between the two groups (27.0 vs. 45.0 d, P = 0.11 on liquid media; 17.0 vs. 42.0 d, P = 0.14 on solid media). Patients in the levofloxacin group had more adverse events than those in the moxifloxacin group (79.2 vs. 63.5%, P = 0.03), especially musculoskeletal ones (37.7 vs. 14.9%, P = 0.001). Conclusions: The choice of levofloxacin or moxifloxacin made no difference to the final treatment outcome among patients with fluoroquinolone-sensitiveMDR-TB.

KW - Fluoroquinolones

KW - Levofloxacin

KW - Moxifloxacin

KW - Multidrug-resistant tuberculosis

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SN - 2325-6621

VL - 13

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EP - 370

JO - Annals of the American Thoracic Society

JF - Annals of the American Thoracic Society

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ER -

Choice between levofloxacin and moxifloxacin and multidrug-resistant tuberculosis treatment outcomes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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