Abstract
This study was undertaken to describe the clinical and imaging characteristics of patients with chorea associated with nonketotic hyperglycemia (C-NKH) in comparison with patients with chorea associated with uremia (C-URE). We retrospectively analyzed the clinical data of consecutive 10 C-NKH and five C-URE patients who were treated between January 1, 2001 and January 31, 2013. Women were more frequently affected by C-NKH (70% vs. 30%) and C-URE (80% vs. 20%) compared with men. The C-NKH patients demonstrated T1-hyperintense and inhomogeneous lesions in the basal ganglia, whereas C-URE patients demonstrated T2-hyperintense and homogeneous lesions in the basal ganglia. The mean time for chorea resolution after treatment was significantly shorter in C-NKH patients than in C-URE patients (4.4±2.6 d vs. 73.8±14.2 d, respectively; P=0.005). The clinical and imaging features are remarkably different between C-NKH and C-URE patients, suggesting distinct pathogenic mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 419-422 |
| Number of pages | 4 |
| Journal | Movement Disorders |
| Volume | 30 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2015 Mar 1 |
| Externally published | Yes |
Bibliographical note
Publisher Copyright:© 2015 International Parkinson and Movement Disorder Society.
Keywords
- Chorea
- Diabetes
- Hyperglycemia
- Magnetic resonance imaging
- Uremia
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
