Chromofluorescent indicator for intracellular Zn2+/Hg 2+ dynamic exchange

Jeong Won Lee; Hyo Sung Jung; Pil Seung Kwon; Jong Wan Kim; Richard A. Bartsch; Youngmee Kim; Sung Jin Kim; Jong Seung Kim

doi:10.1021/ol801482n

Chromofluorescent indicator for intracellular Zn²⁺/Hg ²⁺ dynamic exchange

Jeong Won Lee, Hyo Sung Jung, Pil Seung Kwon, Jong Wan Kim, Richard A. Bartsch, Youngmee Kim, Sung Jin Kim, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

79 Citations (Scopus)

Abstract

(Chemical Equation Presented) (Figure Presented) The fluorescence of NABQ increases remarkably in the presence of Zn²⁺ and is quenched by Hg²⁺. As shown by confocal imaging, NABQ-Zn²⁺ can penetrate cells, where the bound Zn²⁺ is exchanged for Hg ²⁺. This results in the concomitant export of Hg²⁺ from the cells, showing that NABQ can act as a Zn²⁺ carrier and as a Hg²⁺ extracting agent in living cells.

Original language	English
Pages (from-to)	3801-3804
Number of pages	4
Journal	Organic Letters
Volume	10
Issue number	17
DOIs	https://doi.org/10.1021/ol801482n
Publication status	Published - 2008

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol801482n

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title = "Chromofluorescent indicator for intracellular Zn2+/Hg 2+ dynamic exchange",

abstract = "(Chemical Equation Presented) (Figure Presented) The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ-Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg 2+. This results in the concomitant export of Hg2+ from the cells, showing that NABQ can act as a Zn2+ carrier and as a Hg2+ extracting agent in living cells.",

author = "Lee, {Jeong Won} and Jung, {Hyo Sung} and Kwon, {Pil Seung} and Kim, {Jong Wan} and Bartsch, {Richard A.} and Youngmee Kim and Kim, {Sung Jin} and Kim, {Jong Seung}",

year = "2008",

doi = "10.1021/ol801482n",

language = "English",

volume = "10",

pages = "3801--3804",

journal = "Organic Letters",

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publisher = "American Chemical Society",

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TY - JOUR

T1 - Chromofluorescent indicator for intracellular Zn2+/Hg 2+ dynamic exchange

AU - Lee, Jeong Won

AU - Jung, Hyo Sung

AU - Kwon, Pil Seung

AU - Kim, Jong Wan

AU - Bartsch, Richard A.

AU - Kim, Youngmee

AU - Kim, Sung Jin

AU - Kim, Jong Seung

PY - 2008

Y1 - 2008

N2 - (Chemical Equation Presented) (Figure Presented) The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ-Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg 2+. This results in the concomitant export of Hg2+ from the cells, showing that NABQ can act as a Zn2+ carrier and as a Hg2+ extracting agent in living cells.

AB - (Chemical Equation Presented) (Figure Presented) The fluorescence of NABQ increases remarkably in the presence of Zn2+ and is quenched by Hg2+. As shown by confocal imaging, NABQ-Zn2+ can penetrate cells, where the bound Zn2+ is exchanged for Hg 2+. This results in the concomitant export of Hg2+ from the cells, showing that NABQ can act as a Zn2+ carrier and as a Hg2+ extracting agent in living cells.

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U2 - 10.1021/ol801482n

DO - 10.1021/ol801482n

M3 - Article

C2 - 18681453

AN - SCOPUS:55949113887

SN - 1523-7060

VL - 10

SP - 3801

EP - 3804

JO - Organic Letters

JF - Organic Letters

IS - 17

ER -

Chromofluorescent indicator for intracellular Zn²⁺/Hg ²⁺ dynamic exchange

Abstract

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