Chromogenesis-based Resonance Raman molecular sensor for reactive oxygen species

Jeongyun Heo, Chang Keun Lim, Alexander Baev, Andrey N. Kuzmin, Soo Young Park, Paras N. Prasad, Sehoon Kim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Here we report a novel design concept for a molecular sensing platform that specifically generates under non-toxic visible laser excitation, resonance Raman signatures of nitrile (∼2200 cm-1) in response to reactive oxygen species (ROS). The sensing principle employs a ROS-triggered oxidative chromogenic reaction that activates resonance Raman enhancement through chemical transformation of a non-resonant hydrazo molecule into a resonant azo dye with extended π-conjugation. Experimental studies as well as DFT calculation demonstrate that such a design strategy for activatable resonance Raman sensor is valid for selective detection of highly oxidative ROS, hypochlorite ions in the present case, down to 100 ppm.

Original languageEnglish
Pages (from-to)162-167
Number of pages6
JournalDyes and Pigments
Publication statusPublished - 2016 Jul 1
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea ( 2014M3A6B2060522 ), the Intramural Research Program of KIST, and in part by the National Institute of Health ( 1R21EY026411-01 ).


  • Bio-orthogonal Raman scattering
  • Hypochlorite
  • Raman sensor
  • Reactive oxygen species
  • Resonance Raman

ASJC Scopus subject areas

  • General Chemical Engineering
  • Process Chemistry and Technology


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