Chromogenesis-based Resonance Raman molecular sensor for reactive oxygen species

Jeongyun Heo; Chang Keun Lim; Alexander Baev; Andrey N. Kuzmin; Soo Young Park; Paras N. Prasad; Sehoon Kim

doi:10.1016/j.dyepig.2016.03.029

Chromogenesis-based Resonance Raman molecular sensor for reactive oxygen species

Jeongyun Heo
, Chang Keun Lim
, Alexander Baev
, Andrey N. Kuzmin
, Soo Young Park^*
, Paras N. Prasad
, Sehoon Kim

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Here we report a novel design concept for a molecular sensing platform that specifically generates under non-toxic visible laser excitation, resonance Raman signatures of nitrile (∼2200 cm^-1) in response to reactive oxygen species (ROS). The sensing principle employs a ROS-triggered oxidative chromogenic reaction that activates resonance Raman enhancement through chemical transformation of a non-resonant hydrazo molecule into a resonant azo dye with extended π-conjugation. Experimental studies as well as DFT calculation demonstrate that such a design strategy for activatable resonance Raman sensor is valid for selective detection of highly oxidative ROS, hypochlorite ions in the present case, down to 100 ppm.

Original language	English
Pages (from-to)	162-167
Number of pages	6
Journal	Dyes and Pigments
Volume	130
DOIs	https://doi.org/10.1016/j.dyepig.2016.03.029
Publication status	Published - 2016 Jul 1
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by grants from the National Research Foundation of Korea ( 2014M3A6B2060522 ), the Intramural Research Program of KIST, and in part by the National Institute of Health ( 1R21EY026411-01 ).

Keywords

Bio-orthogonal Raman scattering
Hypochlorite
Raman sensor
Reactive oxygen species
Resonance Raman

ASJC Scopus subject areas

General Chemical Engineering
Process Chemistry and Technology

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10.1016/j.dyepig.2016.03.029

Cite this

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title = "Chromogenesis-based Resonance Raman molecular sensor for reactive oxygen species",

abstract = "Here we report a novel design concept for a molecular sensing platform that specifically generates under non-toxic visible laser excitation, resonance Raman signatures of nitrile (∼2200 cm-1) in response to reactive oxygen species (ROS). The sensing principle employs a ROS-triggered oxidative chromogenic reaction that activates resonance Raman enhancement through chemical transformation of a non-resonant hydrazo molecule into a resonant azo dye with extended π-conjugation. Experimental studies as well as DFT calculation demonstrate that such a design strategy for activatable resonance Raman sensor is valid for selective detection of highly oxidative ROS, hypochlorite ions in the present case, down to 100 ppm.",

keywords = "Bio-orthogonal Raman scattering, Hypochlorite, Raman sensor, Reactive oxygen species, Resonance Raman",

author = "Jeongyun Heo and Lim, \{Chang Keun\} and Alexander Baev and Kuzmin, \{Andrey N.\} and Park, \{Soo Young\} and Prasad, \{Paras N.\} and Sehoon Kim",

note = "Funding Information: This work was supported by grants from the National Research Foundation of Korea ( 2014M3A6B2060522 ), the Intramural Research Program of KIST, and in part by the National Institute of Health ( 1R21EY026411-01 ).",

year = "2016",

month = jul,

day = "1",

doi = "10.1016/j.dyepig.2016.03.029",

language = "English",

volume = "130",

pages = "162--167",

journal = "Dyes and Pigments",

issn = "0143-7208",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Chromogenesis-based Resonance Raman molecular sensor for reactive oxygen species

AU - Heo, Jeongyun

AU - Lim, Chang Keun

AU - Baev, Alexander

AU - Kuzmin, Andrey N.

AU - Park, Soo Young

AU - Prasad, Paras N.

AU - Kim, Sehoon

N1 - Funding Information: This work was supported by grants from the National Research Foundation of Korea ( 2014M3A6B2060522 ), the Intramural Research Program of KIST, and in part by the National Institute of Health ( 1R21EY026411-01 ).

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Here we report a novel design concept for a molecular sensing platform that specifically generates under non-toxic visible laser excitation, resonance Raman signatures of nitrile (∼2200 cm-1) in response to reactive oxygen species (ROS). The sensing principle employs a ROS-triggered oxidative chromogenic reaction that activates resonance Raman enhancement through chemical transformation of a non-resonant hydrazo molecule into a resonant azo dye with extended π-conjugation. Experimental studies as well as DFT calculation demonstrate that such a design strategy for activatable resonance Raman sensor is valid for selective detection of highly oxidative ROS, hypochlorite ions in the present case, down to 100 ppm.

AB - Here we report a novel design concept for a molecular sensing platform that specifically generates under non-toxic visible laser excitation, resonance Raman signatures of nitrile (∼2200 cm-1) in response to reactive oxygen species (ROS). The sensing principle employs a ROS-triggered oxidative chromogenic reaction that activates resonance Raman enhancement through chemical transformation of a non-resonant hydrazo molecule into a resonant azo dye with extended π-conjugation. Experimental studies as well as DFT calculation demonstrate that such a design strategy for activatable resonance Raman sensor is valid for selective detection of highly oxidative ROS, hypochlorite ions in the present case, down to 100 ppm.

KW - Bio-orthogonal Raman scattering

KW - Hypochlorite

KW - Raman sensor

KW - Reactive oxygen species

KW - Resonance Raman

UR - https://www.scopus.com/pages/publications/84961769018

UR - https://www.scopus.com/pages/publications/84961769018#tab=citedBy

U2 - 10.1016/j.dyepig.2016.03.029

DO - 10.1016/j.dyepig.2016.03.029

M3 - Article

AN - SCOPUS:84961769018

SN - 0143-7208

VL - 130

SP - 162

EP - 167

JO - Dyes and Pigments

JF - Dyes and Pigments

ER -

Chromogenesis-based Resonance Raman molecular sensor for reactive oxygen species

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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