Chromosomal imbalances in Korean intrahepatic cholangiocarcinoma by comparative genomic hybridization

Kyung Ok Uhm, Young Nyun Park, Ji Young Lee, Dong Seop Yoon, Sun Hwa Park

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26 Citations (Scopus)


Intrahepatic cholangiocarcinoma (ICC) arises from epithelial cells in the intrahepatic bile duct. Until now, only few reports have been available concerning the genetic changes during the progression of ICC. In this study, we analyzed chromosomal aberrations in 19 frozen ICC samples using comparative genomic hybridization. The common chromosomal gains were observed in 8q22∼qter (11 cases, 58%), 5p14∼pter (32%), 2q33∼qter (26%), 7p (26%), 17q21∼q22 (26%), 18q12∼q21 (26%), and 19q13.1 (26%). DNA amplification was identified in nine tumors (47%). Chromosomal loss was found in Y (60%), 1p34∼pter (37%), 4q(32%), 18q21∼qter (32%) 19p (32%), X (32%), 5q11∼q14 (26%), 8p(26%), 9p (26%), and 17p (26%). Chromosomal aberrations identified in this study provide candidate regions involved in the tumorigenesis and progression of ICC.

Original languageEnglish
Pages (from-to)37-41
Number of pages5
JournalCancer Genetics and Cytogenetics
Issue number1
Publication statusPublished - 2005 Feb
Externally publishedYes

Bibliographical note

Funding Information:
This work was supported by a grant from the Medical Science Research Center, Korea University, the Brain Korea 21 Project, and grant no. R04-2000-000-00047-0 from the Basic Research Program of the Korea Science and Engineering Foundation.

Copyright 2008 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research


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