Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder: A longitudinal study based on 4.7 million adults in South Korea

Kyu Man Han, Min Sun Kim, Aram Kim, Jong Woo Paik, Juneyoung Lee, Byung Joo Ham

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea. Methods: The population-based retrospective cohort included data from 2,370,815 adults (age ≥20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age ≥40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD. Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517–8.11), epilepsy (OR = 6.119, 95% CI = 6.019–6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976–6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258–8.909), migraine (OR = 4.374, 95% CI = 4.341–4.408), stroke (OR = 4.074, 95% CI = 4.032–4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041–1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD. Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.

Original languageEnglish
Pages (from-to)486-494
Number of pages9
JournalJournal of Affective Disorders
Volume257
DOIs
Publication statusPublished - 2019 Oct 1

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning ( NRF-2016M3A9A7916996 ) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1A2B4002090 ). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding Information:
The authors declare no conflicts of interest. None. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9A7916996) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1A2B4002090). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

  • Longitudinal
  • Major depressive disorder
  • Metabolic syndrome
  • Physical illness
  • Risk factors

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

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