Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder: A longitudinal study based on 4.7 million adults in South Korea

Kyu Man Han; Min Sun Kim; Aram Kim; Jong Woo Paik; Juneyoung Lee; Byung Joo Ham

doi:10.1016/j.jad.2019.07.003

Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder: A longitudinal study based on 4.7 million adults in South Korea

Kyu Man Han, Min Sun Kim, Aram Kim, Jong Woo Paik, Juneyoung Lee, Byung Joo Ham

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea. Methods: The population-based retrospective cohort included data from 2,370,815 adults (age ≥20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age ≥40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD. Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517–8.11), epilepsy (OR = 6.119, 95% CI = 6.019–6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976–6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258–8.909), migraine (OR = 4.374, 95% CI = 4.341–4.408), stroke (OR = 4.074, 95% CI = 4.032–4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041–1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD. Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.

Original language	English
Pages (from-to)	486-494
Number of pages	9
Journal	Journal of Affective Disorders
Volume	257
DOIs	https://doi.org/10.1016/j.jad.2019.07.003
Publication status	Published - 2019 Oct 1

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning ( NRF-2016M3A9A7916996 ) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1A2B4002090 ). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Funding Information:
The authors declare no conflicts of interest. None. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9A7916996) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1A2B4002090). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Publisher Copyright:
© 2019 Elsevier B.V.

Keywords

Longitudinal
Major depressive disorder
Metabolic syndrome
Physical illness
Risk factors

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jad.2019.07.003

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@article{2051d74edba54b44bc24bc44d32a08df,

title = "Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder: A longitudinal study based on 4.7 million adults in South Korea",

abstract = "Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea. Methods: The population-based retrospective cohort included data from 2,370,815 adults (age ≥20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age ≥40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD. Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517–8.11), epilepsy (OR = 6.119, 95% CI = 6.019–6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976–6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258–8.909), migraine (OR = 4.374, 95% CI = 4.341–4.408), stroke (OR = 4.074, 95% CI = 4.032–4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041–1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD. Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.",

keywords = "Longitudinal, Major depressive disorder, Metabolic syndrome, Physical illness, Risk factors",

author = "Han, {Kyu Man} and Kim, {Min Sun} and Aram Kim and Paik, {Jong Woo} and Juneyoung Lee and Ham, {Byung Joo}",

note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning ( NRF-2016M3A9A7916996 ) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1A2B4002090 ). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: The authors declare no conflicts of interest. None. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9A7916996) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1A2B4002090). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2019 Elsevier B.V.",

year = "2019",

month = oct,

day = "1",

doi = "10.1016/j.jad.2019.07.003",

language = "English",

volume = "257",

pages = "486--494",

journal = "Journal of Affective Disorders",

issn = "0165-0327",

publisher = "Elsevier",

}

TY - JOUR

T1 - Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder

T2 - A longitudinal study based on 4.7 million adults in South Korea

AU - Han, Kyu Man

AU - Kim, Min Sun

AU - Kim, Aram

AU - Paik, Jong Woo

AU - Lee, Juneyoung

AU - Ham, Byung Joo

N1 - Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning ( NRF-2016M3A9A7916996 ) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT ( NRF-2017R1A2B4002090 ). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Funding Information: The authors declare no conflicts of interest. None. This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2016M3A9A7916996) and the Research Program To Solve Social Issues of the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1A2B4002090). The funding agency had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2019 Elsevier B.V.

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea. Methods: The population-based retrospective cohort included data from 2,370,815 adults (age ≥20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age ≥40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD. Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517–8.11), epilepsy (OR = 6.119, 95% CI = 6.019–6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976–6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258–8.909), migraine (OR = 4.374, 95% CI = 4.341–4.408), stroke (OR = 4.074, 95% CI = 4.032–4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041–1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD. Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.

AB - Background: The assessment of comorbid physical illness and metabolic or cardiovascular risk factors as potential risk factors for onset of major depressive disorder (MDD) is crucial. We aimed to investigate potential risk factors for the development of MDD among individuals with chronic medical conditions and metabolic and behavioral risk factors using a large population-based retrospective cohort from the data of the National Health Insurance Service (NHIS) in South Korea. Methods: The population-based retrospective cohort included data from 2,370,815 adults (age ≥20 years) diagnosed with MDD between January 1, 2010, and December 31, 2016 and age- and gender-matched 2,370,815 healthy controls obtained from the claims data of the NHIS. The data of the regular health checkup provided by the NHIS were also included (age ≥40 years). Logistic regression analyses were performed to investigate the potential risk factors for the incidence of MDD. Results: Chronic medical conditions such as Parkinson's disease (odds ratio [OR] = 7.808, 95% confidence interval [CI] = 7.517–8.11), epilepsy (OR = 6.119, 95% CI = 6.019–6.22), multiple sclerosis (OR = 5.532, 95% CI = 4.976–6.151), Huntington's disease (OR = 5.387, 95% CI = 3.258–8.909), migraine (OR = 4.374, 95% CI = 4.341–4.408), stroke (OR = 4.074, 95% CI = 4.032–4.117), and cancer; metabolic syndrome (OR = 1.049, 95% CI = 1.041–1.057) and several of its components including central obesity, elevated fasting blood glucose and triglyceride levels, and reduced high-density lipoprotein level; and cigarette smoking, frequent alcohol consumption, and low physical activity are potential risk factors for the development of MDD. Conclusion: Our results may support previous evidence on the association between physical conditions and the incidence of MDD as reported by individual population-based studies with modest sample sizes.

KW - Longitudinal

KW - Major depressive disorder

KW - Metabolic syndrome

KW - Physical illness

KW - Risk factors

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U2 - 10.1016/j.jad.2019.07.003

DO - 10.1016/j.jad.2019.07.003

M3 - Article

C2 - 31319340

AN - SCOPUS:85068877285

SN - 0165-0327

VL - 257

SP - 486

EP - 494

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

Chronic medical conditions and metabolic syndrome as risk factors for incidence of major depressive disorder: A longitudinal study based on 4.7 million adults in South Korea

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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