Chrysin attenuates progression of ovarian cancer cells by regulating signaling cascades and mitochondrial dysfunction

Whasun Lim, Soomin Ryu, Fuller W. Bazer, Sung Man Kim, Gwonhwa Song

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)

Abstract

Chrysin is mainly found in passion flowers, honey, and propolis acts as a potential therapeutic and preventive agent to inhibit proliferation and invasion of various human cancer cells. Although chrysin has anti-carcinogenic effects in several cancers, little is known about its functional roles in ovarian cancer which shows poor prognosis and chemoresistance to traditional therapeutic agents. In the present study, we investigated functional roles of chrysin in progression of ovarian cancer cells using ES2 and OV90 (clear cell and serous carcinoma, respectively) cell lines. Results of the current study demonstrated that chrysin inhibited ovarian cancer cell proliferation and induced cell death by increasing reactive oxygen species (ROS) production and cytoplasmic Ca2+ levels as well as inducing loss of mitochondrial membrane potential (MMP). Moreover, chrysin activated mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT pathways in ES2 and OV90 cells in concentration-response experiments. Collectively, our results led us to propose that chrysin-induced apoptotic events are mediated by the activation of PI3K and MAPK pathways in human ovarian cancer cells.

Original languageEnglish
Pages (from-to)3129-3140
Number of pages12
JournalJournal of Cellular Physiology
Volume233
Issue number4
DOIs
Publication statusPublished - 2018 Apr

Bibliographical note

Funding Information:
This research was funded by Basic Science Research Program (2015R1D1A1A01059331) through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science, and Technology. In addition, this research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C0929).

Funding Information:
Ministry of Education, Science, and Technology (Republic of Korea); Basic Science Research Program through National Research Foundation of Korea (NRF), Grant number: 2015R1D1A1A01059331; Korea Health Technology R&D Project through Korea Health Industry Development Institute (KHIDI); Ministry of Health & Welfare (Republic of Korea), Grant number: HI17C0929

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.

Keywords

  • Apoptosis
  • Chrysin
  • Mitochondrial dysfunction
  • Ovarian cancer
  • Signaling pathways

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Cell Biology

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