Circulating biomarkers for diagnosis and therapeutic monitoring in bone metastasis

Min Kyoung Song, Serk In Park, Sun Wook Cho

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


Bone is a frequent site of metastasis for multiple types of solid tumors in organs such as prostate, breast, lung, etc., accounting for significant morbidities and mortalities of afflicted patients. One of the major problems of bone metastasis is lack of biomarkers for early diagnosis and for monitoring therapeutic responses. Medical imaging modalities such as computerized tomography, magnetic resonance imaging, and radioactive isotope-based bone scans are currently standard clinical practices, yet these imaging techniques are limited to detect early lesions or to accurately monitor the metastatic disease progression during standard and/or experimental therapies. Accordingly, development of novel blood biomarkers rationalizes extensive basic research and clinical development. This review article covers the up-to-date information on protein- and cell-based biomarkers of bone metastasis that are currently used in the clinical practices and also are under development.

Original languageEnglish
Pages (from-to)337-344
Number of pages8
JournalJournal of Bone and Mineral Metabolism
Issue number3
Publication statusPublished - 2023 May

Bibliographical note

Funding Information:
This study was supported by the National R&D Program for Cancer Control, the Ministry of Health and Welfare, the Republic of Korea (HA17C0040) and the National Research Foundation of Korea (2019R1A2C1085672, 2020R1A2C1012966 and 2022R1A6A3A01087551).

Publisher Copyright:
© 2023, The Japanese Society Bone and Mineral Research.


  • Bone metastases
  • Bone metastatic cancers
  • Bone microenvironment
  • Bone turnover markers
  • Circulating biomarkers

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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