ClC Chloride Channels in Gram-Negative Bacteria and Its Role in the Acid Resistance Systems

Minjeong Kim, Nakjun Choi, Eunna Choi, Eun Jin Lee

Research output: Contribution to journalReview articlepeer-review


Pathogenic bacteria that colonize the human intestinal tract have evolved strategies to overcome acidic conditions when they pass through the gastrointestinal tract. Amino acid-mediated acid resistance systems are effective survival strategies in a stomach that is full of amino acid substrate. The amino acid antiporter, amino acid decarboxylase, and ClC chloride antiporter are all engaged in these systems, and each one plays a role in protecting against or adapting to the acidic environment. The ClC chloride antiporter, a member of the ClC channel family, eliminates negatively charged intracellular chloride ions to avoid inner membrane hyperpolarization as an electrical shunt of the acid resistance system. In this review, we will discuss the structure and function of the prokaryotic ClC chloride antiporter of amino acid-mediated acid resistance system.

Original languageEnglish
Pages (from-to)857-863
Number of pages7
JournalJournal of microbiology and biotechnology
Issue number7
Publication statusPublished - 2023 Jul 28

Bibliographical note

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Copyright © 2023 by the authors.


  • ClC channel
  • acid resistance
  • chloride antiporter
  • clcA

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology


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