Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

Yuan Shuo, Chenyue Zhang, Xueyuan Yang, Feng Liu, Qi Zhang, Annan Li, Jun Ma, Dongho Lee, Yasushi Ohizumi, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Abstract: A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1–4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. Graphic abstract: [Figure not available: see fulltext.].

Original languageEnglish
Pages (from-to)826-833
Number of pages8
JournalJournal of Natural Medicines
Issue number4
Publication statusPublished - 2019 Sept 13

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the National University Student Innovation Program of Nankai University, the National Natural Science Foundation of China (No. U1703107), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and Hundred Young Academic Leaders Program of Nankai University.

Publisher Copyright:
© 2019, The Japanese Society of Pharmacognosy.


  • Apoptosis
  • Casearia kurzii
  • Cell cycle
  • Clerodane diterpenoids
  • Cytotoxic activities

ASJC Scopus subject areas

  • Drug Discovery
  • Complementary and alternative medicine
  • Pharmaceutical Science
  • Organic Chemistry


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