Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

Yuan Shuo; Chenyue Zhang; Xueyuan Yang; Feng Liu; Qi Zhang; Annan Li; Jun Ma; Dongho Lee; Yasushi Ohizumi; Yuanqiang Guo

doi:10.1007/s11418-019-01324-5

Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

Yuan Shuo, Chenyue Zhang, Xueyuan Yang, Feng Liu, Qi Zhang, Annan Li, Jun Ma, Dongho Lee, Yasushi Ohizumi, Yuanqiang Guo

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Abstract: A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1–4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC₅₀ value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. Graphic abstract: [Figure not available: see fulltext.].

Original language	English
Pages (from-to)	826-833
Number of pages	8
Journal	Journal of Natural Medicines
Volume	73
Issue number	4
DOIs	https://doi.org/10.1007/s11418-019-01324-5
Publication status	Published - 2019 Sept 13

Bibliographical note

Funding Information:
Acknowledgements This work was supported by the National University Student Innovation Program of Nankai University, the National Natural Science Foundation of China (No. U1703107), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and Hundred Young Academic Leaders Program of Nankai University.

Publisher Copyright:
© 2019, The Japanese Society of Pharmacognosy.

Keywords

Apoptosis
Casearia kurzii
Cell cycle
Clerodane diterpenoids
Cytotoxic activities

ASJC Scopus subject areas

Drug Discovery
Complementary and alternative medicine
Pharmaceutical Science
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11418-019-01324-5

Cite this

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title = "Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities",

abstract = "Abstract: A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1–4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. Graphic abstract: [Figure not available: see fulltext.].",

keywords = "Apoptosis, Casearia kurzii, Cell cycle, Clerodane diterpenoids, Cytotoxic activities",

author = "Yuan Shuo and Chenyue Zhang and Xueyuan Yang and Feng Liu and Qi Zhang and Annan Li and Jun Ma and Dongho Lee and Yasushi Ohizumi and Yuanqiang Guo",

note = "Funding Information: Acknowledgements This work was supported by the National University Student Innovation Program of Nankai University, the National Natural Science Foundation of China (No. U1703107), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and Hundred Young Academic Leaders Program of Nankai University. Publisher Copyright: {\textcopyright} 2019, The Japanese Society of Pharmacognosy.",

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doi = "10.1007/s11418-019-01324-5",

language = "English",

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T1 - Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

AU - Shuo, Yuan

AU - Zhang, Chenyue

AU - Yang, Xueyuan

AU - Liu, Feng

AU - Zhang, Qi

AU - Li, Annan

AU - Ma, Jun

AU - Lee, Dongho

AU - Ohizumi, Yasushi

AU - Guo, Yuanqiang

N1 - Funding Information: Acknowledgements This work was supported by the National University Student Innovation Program of Nankai University, the National Natural Science Foundation of China (No. U1703107), the Natural Science Foundation of Tianjin, China (No. 16JCYBJC27700), and Hundred Young Academic Leaders Program of Nankai University. Publisher Copyright: © 2019, The Japanese Society of Pharmacognosy.

PY - 2019/9/13

Y1 - 2019/9/13

N2 - Abstract: A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1–4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. Graphic abstract: [Figure not available: see fulltext.].

AB - Abstract: A search for bioactive natural products as anticancer lead compounds resulted in the isolation of one previously undescribed and three known clerodane diterpenoids (1–4) from Casearia kurzii. The structures of these compounds were established by analysis of their NMR, MS, and electronic circular dichroism data. The cytotoxic activities of four compounds against three human cancer cell lines were evaluated. Compound 2 was found to be the most active with an IC50 value of 4.1 μM against HeLa cells, and was selected to investigate the possible cytotoxic mechanism. Graphic abstract: [Figure not available: see fulltext.].

KW - Apoptosis

KW - Casearia kurzii

KW - Cell cycle

KW - Clerodane diterpenoids

KW - Cytotoxic activities

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DO - 10.1007/s11418-019-01324-5

M3 - Article

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SN - 1340-3443

VL - 73

SP - 826

EP - 833

JO - Journal of Natural Medicines

JF - Journal of Natural Medicines

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ER -

Clerodane diterpenoids from Casearia kurzii and their cytotoxic activities

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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