Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens

Feng Liu; Jun Ma; Zhaoyu Shi; Qi Zhang; Huimei Wang; Dihua Li; Zhaohui Song; Chunyan Wang; Jin Jin; Jing Xu; Muhetaer Tuerhong; Munira Abudukeremu; Ling Shuai; Dongho Lee; Yuanqiang Guo

doi:10.1021/acs.jnatprod.9b00515

Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens

Feng Liu, Jun Ma, Zhaoyu Shi, Qi Zhang, Huimei Wang, Dihua Li, Zhaohui Song, Chunyan Wang, Jin Jin, Jing Xu, Muhetaer Tuerhong, Munira Abudukeremu, Ling Shuai, Dongho Lee, Yuanqiang Guo

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce apoptosis of A549 cells and impede them at the G₀/G₁ stage.

Original language	English
Pages (from-to)	36-44
Number of pages	9
Journal	Journal of Natural Products
Volume	83
Issue number	1
DOIs	https://doi.org/10.1021/acs.jnatprod.9b00515
Publication status	Published - 2020 Jan 24

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acs.jnatprod.9b00515

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title = "Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens",

abstract = "A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce apoptosis of A549 cells and impede them at the G0/G1 stage.",

author = "Feng Liu and Jun Ma and Zhaoyu Shi and Qi Zhang and Huimei Wang and Dihua Li and Zhaohui Song and Chunyan Wang and Jin Jin and Jing Xu and Muhetaer Tuerhong and Munira Abudukeremu and Ling Shuai and Dongho Lee and Yuanqiang Guo",

note = "Funding Information: This research was supported financially by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107 and U1801288), the Natural Science Foundation of Tianjin (No. 19JCYBJC28100), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2019-B01), and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019). Publisher Copyright: {\textcopyright} 2020 American Chemical Society and American Society of Pharmacognosy.",

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doi = "10.1021/acs.jnatprod.9b00515",

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journal = "Journal of Natural Products",

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AU - Liu, Feng

AU - Ma, Jun

AU - Shi, Zhaoyu

AU - Zhang, Qi

AU - Wang, Huimei

AU - Li, Dihua

AU - Song, Zhaohui

AU - Wang, Chunyan

AU - Jin, Jin

AU - Xu, Jing

AU - Tuerhong, Muhetaer

AU - Abudukeremu, Munira

AU - Shuai, Ling

AU - Lee, Dongho

AU - Guo, Yuanqiang

N1 - Funding Information: This research was supported financially by the National Key Research and Development Program of China (No. 2018YFA0507204), the National Natural Science Foundation of China (Nos. U1703107 and U1801288), the Natural Science Foundation of Tianjin (No. 19JCYBJC28100), Hundred Young Academic Leaders Program of Nankai University, State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Guangxi Normal University, No. CMEMR2019-B01), and the open project of Key Laboratory of Xinjiang Uygur Autonomous Region (Nos. 2015KL030 and 2017D04019). Publisher Copyright: © 2020 American Chemical Society and American Society of Pharmacognosy.

PY - 2020/1/24

Y1 - 2020/1/24

N2 - A phytochemical survey aiming to acquire pharmacologically active substances has resulted in the isolation of nine new clerodane diterpenoids, named graveospenes A-I (1-9), from the leaves of Casearia graveolens. Spectroscopic methods were employed to establish the structures with their absolute configurations being confirmed by ECD data analysis. A biological evaluation was performed, and compound 1 was found to be cytotoxic to both human lung cancer cells (A549) and human hepatocellular carcinoma cells (HepG2). A mechanism-of-action study on 1 revealed this compound to induce apoptosis of A549 cells and impede them at the G0/G1 stage.

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Clerodane Diterpenoids Isolated from the Leaves of Casearia graveolens

Abstract

ASJC Scopus subject areas

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