Clinical and economic outcomes in medication-adherent and -nonadherent patients with type 2 diabetes mellitus in the republic of Korea

So Yeon An, Hae Jin Kim, Ki Hong Chun, Tae Ho Kim, Ja Young Jeon, Dae Jung Kim, Seung Jin Han, Young Seol Kim, Jeong Taek Woo, Kyu Jeung Ahn, Yongsoo Park, Moonsuk Nam, Sei Hyun Baik, Kwan Woo Lee

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    Background The prevalence and social burden of type 2 diabetes mellitus (T2DM) is increasing. Medication adherence is necessary for positive outcomes in patients with T2DM. Objective This study evaluated the association between medication adherence and clinical/economic outcomes in patients with T2DM in the Republic of Korea over a 3-year period. Methods This study used data from the Korean National Diabetes Program at 5 hospitals. Medication possession ratios of ≥90% and <90% were used to define adherent and nonadherent groups, respectively. The degree of glycemic control, changes in blood pressure and lipid profiles, and health care costs were compared. Results Of the 608 patients, 472 were medication adherent and 136 were nonadherent. The adherent patients displayed improved fasting blood glucose and hemoglobin A1c during the study. Diastolic blood pressure and total cholesterol were lower at 36 months, and lower low-density lipoprotein cholesterol was noted at baseline and 24 months. The total health care costs were $1861, $2060, and $1924, respectively, versus $1617, $1751, and $1602 during the 3-year study period for the adherent group versus the nonadherent group, respectively (P = 0.316, 0.627, and 0.172, respectively), whereas the outpatient drug costs were $1143, $1176, and $1162 in the adherent group versus $925, $778, and $914 in the nonadherent group (P = 0.002, P < 0.001, and P = 0.001). Conclusions The adherent patients displayed better glycemic control and lipid profiles. Medication-related expenses were higher in the adherent group, but overall health care costs, including hospitalization costs, were similar between the 2 groups.

    Original languageEnglish
    Pages (from-to)245-254
    Number of pages10
    JournalClinical Therapeutics
    Issue number2
    Publication statusPublished - 2014 Feb 1

    Bibliographical note

    Funding Information:
    This study was supported by a grant no. HI10C2020 from Korea Healthcare Technology, R&D Project, Ministry of Health and Welfare, Republic of Korea.Dr. An analyzed the data and wrote the paper. Drs. H.J. Kim, Chun, T.H. Kim, Jeon, D.J. Kim and Han collected and analyzed the data. Drs. Y.S. Kim, Woo, Ahn, Park, Nam and Baik collected the data. Dr. Lee was responsible for the research design, data collection, data analysis and writing of the paper.


    • adherence to medication
    • clinical and economic outcomes
    • type 2 diabetes mellitus

    ASJC Scopus subject areas

    • Pharmacology
    • Pharmacology (medical)


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