Clinical characteristics of late-onset neuromyelitis optica spectrum disorder: A multicenter retrospective study in Korea

Jin Myoung Seok, Hye Jin Cho, Suk Won Ahn, Eun Bin Cho, Min Su Park, In Soo Joo, Ha Young Shin, Sun Young Kim, Byung Jo Kim, Jong Kuk Kim, Joong Yang Cho, So Young Huh, Ohyun Kwon, Kwang Ho Lee, Byoung Joon Kim, Ju Hong Min

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    58 Citations (Scopus)


    Background: There are currently few studies regarding late-onset neuromyelitis optica spectrum disorder (LO-NMOSD). Objective: We aimed to describe the characteristic features of patients with LO-NMOSD in Korea. Methods: Anti-aquaporin-4 antibody-positive patients with neuromyelitis optica spectrum disorder (NMOSD) from nine tertiary hospitals were reviewed retrospectively. The patients were divided into two groups based on age of onset: LO-NMOSD (⩾50 years of age at onset) versus early-onset neuromyelitis optica spectrum disorder (EO-NMOSD) (<50 years of age at onset). Clinical, laboratory, and magnetic resonance imaging (MRI) parameters were investigated. Results: Among a total of 147 patients (125 female; age of onset, 39.4 ± 15.2 years), 45 patients (30.6%) had an age of onset of more than 50 years. Compared to patients with EO-NMOSD, patients with LO-NMOSD had more frequent isolated spinal cord involvement at onset (64.4% vs 37.2%, p = 0.002), less frequent involvement of the optic nerve (40.0% vs 67.7%, p = 0.002), and less frequent brain MRI lesions (31.1% vs 50.0%, p = 0.034). Furthermore, there was a significant positive correlation between age of onset and Expanded Disability Status Scale (EDSS) score at last follow-up (r = 0.246, p = 0.003). Conclusion: Age of onset could be an important predictor of lesion location and clinical course of patients with NMOSD.

    Original languageEnglish
    Pages (from-to)1748-1756
    Number of pages9
    JournalMultiple Sclerosis
    Issue number13
    Publication statusPublished - 2017 Nov 1


    • age of onset
    • late-onset neuromyelitis optica
    • Neuromyelitis optica (NMO)
    • neuromyelitis optica spectrum disorder (NMOSD)
    • seropositive neuromyelitis optica spectrum disorder

    ASJC Scopus subject areas

    • Neurology
    • Clinical Neurology


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