Clinical features and treatment outcomes of upper gastrointestinal bleeding in patients with cirrhosis

Seok Seo Yeon, Ho Kim Youn, Hoon Ahn Sang, Kyun Yu Sang, Koo Baik Soon, Kyu Choi Sung, Jeong Heo, Taeho Hahn, Woo Yoo Tae, Hyun Cho Se, Woong Lee Hyun, Hyun Kim Ju, Mong Cho, Hoon Park Sang, Ik Kim Byung, Hyub Han Kwang, Ho Um Soon

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)


With recent progress in treatment modalities, mortality from upper gastrointestinal (UGI) bleeding has decreased appreciably. The aim of this study was to establish how UGI bleeds are managed in Korean patients with cirrhosis and to evaluate treatment outcomes. A total of 479 episodes of acute UGI bleeding in 464 patients with cirrhosis were included during a six-month period at nine tertiary medical centers. Treatment outcomes were assessed by failure to control bleeding, rebleeding and mortality. The source of bleeding was esophagogastric varices in 77.7% of patients, nonvariceal lesions in 15.9%, and undefined in 6.5%. For control of bleeding, endoscopic and pharmacologic treatments were used in 74.7% and 81.9% of patients, respectively. Variceal ligation was a major technique for endoscopic treatment (90%), and terlipressin and somatostatin were the main pharmacologic agents used (96.4%). Initial hemostasis was achieved in 86.8% of cases, but rebleeding occurred in 3.8% and 16.8% of cases within five days and six weeks of hemorrhage, respectively. Five-day and six-week mortality were 11.3% and 25.9%, respectively. Survival of patients with variceal bleeding seems to be remarkably improved than previous reports, which may suggest the advances in hemostatic methods for control of variceal hemorrhage.

Original languageEnglish
Pages (from-to)635-643
Number of pages9
JournalJournal of Korean medical science
Issue number4
Publication statusPublished - 2008 Aug
Externally publishedYes


  • Hemorrhage
  • Hemostasis
  • Liver cirrhosis
  • Prevention and control
  • Prognosis
  • Varicose veins

ASJC Scopus subject areas

  • General Medicine


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