Clinical investigation of women with asthma worsened during pregnancy

Hwan Kwon Young Hwan Kwon, Kyu Kim Kyung Kyu Kim, Cheol Jung Hye Cheol Jung, Yong Lee Sung Yong Lee, Hyeong Kim Je Hyeong Kim, Ra Lee So Ra Lee, Yeub Lee Sang Yeub Lee, Hyeong Lee Sin Hyeong Lee, Yun Cho Jae Yun Cho, Jeong Shim Jae Jeong Shim, Ho Kang Kyung Ho Kang, Hwa Yoo Se Hwa Yoo, Ho In Kwang Ho In

Research output: Contribution to journalArticlepeer-review


Background: Asthma is the most common respiratory crisis encountered in clinical practice, occurring in up to 4% of all pregnancies. Pregnancy often appears to alter the course of asthma. But the mechanisms responsible for variable changes in the asthma course during pregnancy remain unknown. Poor control and exacerbations of asthma during pregnancy may result in serious maternal and fetal complications. To investigate the course of asthma during pregnancy in korean women, we did a retrograde study of 27 pregnant women who had been admitted to Korea University Hospital for asthma worsened. Method: Twenty seven pregnant women who had been visited to Korea University Hospital for asthma worsened were enrolled in our retrospective study. We reviewed medical recordings and interviewed patients with asthma. Results: Twenty seven pregnant women with asthma were evaluated, and 25 patients were enrolled to our study. Two patients experienced abortions at 6 weeks and 25 weeks gestation, respectively. The period of asthma worsened was commonly during weeks 20 to 28 of gestation. And all patients worsened were improved during the last 4 weeks of pregnancy. Twenty (80%) of 25 women whose asthma worsened during pregnancy reverted toward their prepregnancy status after delivery (p<0.002). The causes of asthma worsened during pregnancy are reduction or even complete cessation of medication due to fears about its safety (40%), worsening after upper respiratory infection (28%), and unknown (32%). There were no adverse perinatal outcomes in 25 pregnant asthma subjects. Conclusions: A major problem of therapy for asthma during pregnancy is reduction or even complete cessation of medication due to fears of fetal effects. Therefore, maternal education and optimal clinical and pharmacologic management is necessary to mitigate maternal and fetal complications.

Original languageEnglish
Pages (from-to)548-554
Number of pages7
JournalTuberculosis and Respiratory Diseases
Issue number4
Publication statusPublished - 1999
Externally publishedYes


  • Asthma
  • Pregnancy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Infectious Diseases


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