Abstract
Background/Aims: The efficacy of standard triple therapy (STT) in treating Helicobacter pylori infection has decreased. Many investigators have attempted to increase the eradication rate. We investigated the outcomes of concomitant therapy (CT) and STT combined with probiotics (STP) as a first-line treatment for H. pylori infection. Methods: We reviewed the medical records of 361 patients who received either STP (n=286) or CT (n=75). The STP group received STT combined with a probiotic preparation for 1 week. The CT group received STT and metronidazole for 1 week. Results: The intention-to-treat and per-protocol eradication rates were 83.6% (95% confidence interval [CI], 79.0 to 87.7) and 87.1% (95% CI, 81.2 to 89.7) in the STP group and 86.7% (95% CI, 78.7 to 93.3) and 91.4% (95% CI, 83.6 to 97.1) in the CT group (p=0.512 and p=0.324), respectively. The frequency of adverse effects was higher in the CT group (28.2%) than in the STP group (12.8%) (p=0.002). Conclusions: STP and CT are encouragingly efficacious as first-line treatments for H. pylori infection. Therefore, adding probiotics to STT may be a feasible option to avoid side effects. (Gut Liver 2018;12:165-172).
Original language | English |
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Pages (from-to) | 165-172 |
Number of pages | 8 |
Journal | Gut and liver |
Volume | 12 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2018 Mar |
Bibliographical note
Publisher Copyright:© This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License
Keywords
- Helicobacter pylori
- Metronidazole
- Probiotics
ASJC Scopus subject areas
- Hepatology
- Gastroenterology