Clinical Usefulness of Computational Modeling-Guided Persistent Atrial Fibrillation Ablation: Updated Outcome of Multicenter Randomized Study

For the CUVIA-AF1 Investigators

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    17 Citations (Scopus)


    Objective: Catheter ablation of persistent atrial fibrillation (AF) is still challenging, no optimal extra-pulmonary vein lesion set is known. We previously reported the clinical feasibility of computational modeling-guided AF catheter ablation. Methods: We randomly assigned 118 patients with persistent AF (77.8% men, age 60.8 ± 9.9 years) to the computational modeling-guided ablation group (53 patients) and the empirical ablation group (55 patients) based on the operators’ experience. For virtual ablation, four virtual linear and one electrogram-guided lesion sets were tested on patient heart computed tomogram-based models, and the lesion set with the fastest termination time was reported to the operator in the modeling-guided ablation group. The primary outcome was freedom from atrial tachyarrhythmias lasting longer than 30 s after a single procedure. Results: During 31.5 ± 9.4 months, virtual ablation procedures were available in 95.2% of the patients (108/118). Clinical recurrence rate was significantly lower after a modeling-guided ablation than after an empirical ablation (20.8 vs. 40.0%, log-rank p = 0.042). Modeling-guided ablation was independently associated with a better long-term rhythm outcome of persistent AF ablation (HR = 0.29 [0.12–0.69], p = 0.005). The rhythm outcome of the modeling-guided ablation showed better trends in males, non-obese patients with a less remodeled atrium (left atrial dimension < 50 mm), ejection fraction ≥ 50%, and those without hypertension or diabetes (p < 0.01). There were no significant differences between the groups for the total procedure time (p = 0.403), ablation time (p = 0.510), and major complication rate (p = 0.900). Conclusion: Among patients with persistent AF, the computational modeling-guided ablation was superior to the empirical catheter ablation regarding the rhythm outcome. Clinical Trial Registration: This study was registered with the, number NCT02171364.

    Original languageEnglish
    Article number1512
    JournalFrontiers in Physiology
    Publication statusPublished - 2019 Dec 17

    Bibliographical note

    Funding Information:
    This work was supported by a grant HI18C0070 and HI19C0114 from the Ministry of Health and Welfare and a grant NRF-2017R1A2B4003983 from the Basic Science Research Program run by the National Research Foundation of Korea (NRF) which is funded by the Ministry of Science, ICT & Future Planning (MSIP). As a medical writer, I-SK wrote this manuscript without any grants.

    Publisher Copyright:
    © Copyright © 2019 Kim, Lim, Shim, Hwang, Yu, Kim, Uhm, Kim, Joung, On, Oh, Oh, Nam, Lee, Shim, Kim and Pak.


    • atrial fibrillation
    • catheter ablation
    • computational modeling
    • recurrence
    • virtual ablation

    ASJC Scopus subject areas

    • Physiology
    • Physiology (medical)


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