Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma

Hyo Jung Kim, Jae Seon Kim, Baek-Hui Kim, Young-Tae Bak

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)


    Backgrounds and Aims: Biliary intraepithelial neoplasia (BilIN) is a precursor of cholangiocarcinoma (CC) and it has been associated with several chronic inflammatory conditions. This study aimed to elucidate the prevalence of BilIN in CC and its clinicopathological significance. Methods: Medical records of 193 patients with histologically confirmed CC were analyzed. We reviewed the pathology findings of 48 patients who underwent curative surgery for CC. Results: Of the 48 patients analyzed, 34 and 14 patients had extrahepatic and intrahepatic CC respectively. BilIN was detected in 28 patients (58%) and showed a significantly higher prevalence in extrahepatic CC (75%) than in intrahepatic CC (21%; p < 0.001). In the subgroup of 34 patients with extrahepatic CC, 25 and 9 patients were BilIN positive and negative respectively. Poor differentiation and T3 stage were significantly more common in the BilIN-negative group than in the BilIN-positive group (p < 0.05). The expression of MUC5AC, p53, and loss of Smad4 showed no difference between BilIN-positive CC and in BilIN-negative CC, but the Ki-67 expression was significantly higher (p < 0.05). Conclusion: BilIN-positive CC showed less invasiveness than negative cases. The Ki-67 expression was significantly higher in BilIN-positive CC.

    Original languageEnglish
    JournalDigestive Surgery
    Publication statusAccepted/In press - 2017 May 11


    • Biliary intraepithelial neoplasia
    • Cholangiocarcinoma
    • Ki-67

    ASJC Scopus subject areas

    • Surgery
    • Gastroenterology


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