Clusterin overexpression protects against western diet-induced obesity and NAFLD

Jin Sung Park, Woon Kyu Lee, Hyeon Soo Kim, Ji A Seo, Dong Hoon Kim, Hee Chul Han, Bon Hong Min

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Obesity is a significant risk factor for various metabolic diseases and is closely related to non-alcoholic fatty liver disease (NAFLD) characterized by inflammation and oxidative stress. Clusterin is a multi-functional protein that is up-regulated in the pathogenesis of various metabolic diseases, including obesity and NAFLD. Our previous studies indicated that hepatocyte-specific overexpression of clusterin alleviates methionine choline-deficient (MCD) diet-induced non-alcoholic steatohepatitis (NASH) by activating nuclear factor erythroid 2-related factor 2 (Nrf2). Here we generated transgenic mice with whole-body clusterin overexpression (wCLU-tg) and investigated the role of clusterin in Western diet-induced obesity and NAFLD. We confirmed that obesity parameters and the spectrum of NAFLD of wCLU-tg mice were improved compared to wild type mice. Contrarily, clusterin deficiency deteriorated metabolic disruptions. We also found that clusterin activates target molecules for obesity and NAFLD, namely Nrf2 and AMPK, suggesting that clusterin protects against Western diet-induced obesity and NAFLD by activating Nrf2 and AMPK.

Original languageEnglish
Article number17484
JournalScientific reports
Issue number1
Publication statusPublished - 2020 Dec 1

Bibliographical note

Funding Information:
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (grant numbers: 2015R1D1A1A01058467 and 2018R1D1A1B07051085).

Publisher Copyright:
© 2020, The Author(s).

ASJC Scopus subject areas

  • General


Dive into the research topics of 'Clusterin overexpression protects against western diet-induced obesity and NAFLD'. Together they form a unique fingerprint.

Cite this