Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells

Yong Ryu Shi Yong Ryu; Youn Kou Na Youn Kou; Seok Choi Hong Seok Choi; H. Ryu; Sung Kim Tae Sung Kim; Man Kim Kyeong Man Kim

doi:10.1055/s-2001-11509

Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells

Yong Ryu Shi Yong Ryu, Youn Kou Na Youn Kou, Seok Choi Hong Seok Choi, H. Ryu, Sung Kim Tae Sung Kim, Man Kim Kyeong Man Kim

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC₅₀ value, 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC₅₀ value, 7.5 μM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.

Original language	English
Pages (from-to)	172-174
Number of pages	3
Journal	Planta Medica
Volume	67
Issue number	2
DOIs	https://doi.org/10.1055/s-2001-11509
Publication status	Published - 2001
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells",

abstract = "Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 μM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.",

author = "{Shi Yong Ryu}, {Yong Ryu} and {Na Youn Kou}, {Youn Kou} and {Hong Seok Choi}, {Seok Choi} and H. Ryu and {Tae Sung Kim}, {Sung Kim} and {Kyeong Man Kim}, {Man Kim}",

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T1 - Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells

AU - Shi Yong Ryu, Yong Ryu

AU - Na Youn Kou, Youn Kou

AU - Hong Seok Choi, Seok Choi

AU - Ryu, H.

AU - Tae Sung Kim, Sung Kim

AU - Kyeong Man Kim, Man Kim

PY - 2001

Y1 - 2001

N2 - Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 μM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.

AB - Cnidicin (1) and five related coumarins were isolated from the root extract of Angelica koreana (Umbelliferae) as active principles responsible for the inhibitory effect on the degranulation process of cultured mast cells. Cnidicin (1) demonstrated a significant inhibition upon the release of β-hexosaminidase from the cultured RBL-2H3 cells in a dose dependent manner (IC50 value, 25 μM) and upon the nitric oxide production from the activated RAW264.7 cells (IC50 value, 7.5 μM). In agreement with this, cnidicin inhibited the expression of nitric oxide synthase in RAW264.7 cells.

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SN - 0032-0943

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Cnidicin, a coumarin, from the root of Angelica koreana, inhibits the degranulation of mast cell and the NO generation in RAW 264.7 cells

Abstract

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