Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials

Ki Young Jung; Jae Wook Cho; Eun Yeon Joo; Sun Hwa Kim; Kyung Mook Choi; Juhee Chin; Kun Woo Park; Seung Bong Hong

doi:10.1016/j.clinph.2010.03.013

Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials

Ki Young Jung, Jae Wook Cho, Eun Yeon Joo, Sun Hwa Kim, Kyung Mook Choi, Juhee Chin, Kun Woo Park, Seung Bong Hong

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.

Original language	English
Pages (from-to)	1494-1501
Number of pages	8
Journal	Clinical Neurophysiology
Volume	121
Issue number	9
DOIs	https://doi.org/10.1016/j.clinph.2010.03.013
Publication status	Published - 2010 Sept

Bibliographical note

Funding Information:
This work was supported by Grant (2009K001257) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of the Republic of Korea, by the Samsung Biomedical Research Institute grant, #SBRI C-B0-237-1 and by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A090794).

Keywords

Cognitive function
Event-related potential (ERP)
Source localisation
Standardised low-resolution electromagnetic tomography (sLORETA)
Topiramate

ASJC Scopus subject areas

Sensory Systems
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.clinph.2010.03.013

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title = "Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials",

abstract = "Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.",

keywords = "Cognitive function, Event-related potential (ERP), Source localisation, Standardised low-resolution electromagnetic tomography (sLORETA), Topiramate",

author = "Jung, {Ki Young} and Cho, {Jae Wook} and Joo, {Eun Yeon} and Kim, {Sun Hwa} and Choi, {Kyung Mook} and Juhee Chin and Park, {Kun Woo} and Hong, {Seung Bong}",

note = "Funding Information: This work was supported by Grant (2009K001257) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of the Republic of Korea, by the Samsung Biomedical Research Institute grant, #SBRI C-B0-237-1 and by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A090794).",

year = "2010",

month = sep,

doi = "10.1016/j.clinph.2010.03.013",

language = "English",

volume = "121",

pages = "1494--1501",

journal = "Clinical Neurophysiology",

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T1 - Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials

AU - Jung, Ki Young

AU - Cho, Jae Wook

AU - Joo, Eun Yeon

AU - Kim, Sun Hwa

AU - Choi, Kyung Mook

AU - Chin, Juhee

AU - Park, Kun Woo

AU - Hong, Seung Bong

N1 - Funding Information: This work was supported by Grant (2009K001257) from the Brain Research Center of the 21st Century Frontier Research Program funded by the Ministry of Science and Technology of the Republic of Korea, by the Samsung Biomedical Research Institute grant, #SBRI C-B0-237-1 and by a grant of the Korea Healthcare technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea (A090794).

PY - 2010/9

Y1 - 2010/9

N2 - Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.

AB - Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.

KW - Cognitive function

KW - Event-related potential (ERP)

KW - Source localisation

KW - Standardised low-resolution electromagnetic tomography (sLORETA)

KW - Topiramate

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Cognitive effects of topiramate revealed by standardised low-resolution brain electromagnetic tomography (sLORETA) of event-related potentials

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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