Abstract
Objective: To evaluate the effect of topiramate (TPM) on event-related potentials (ERPs) in patients with epilepsy. Methods: Neuropsychological tests and ERP study using auditory oddball paradigm were conducted before and after treatment with TPM in drug-naive epilepsy patients. To detect target brain regions in which ERP changed during the cognitive task, cortical current densities of ERP components were analysed using standardised low-resolution electromagnetic tomography (sLORETA). Results: Neuropsychological tests (n=18 patients) showed that TPM significantly decreased the score in digit span, Corsi block and Controlled Oral Word Association word fluency. Repeated-measures analysis of variance of ERP data (n=13 patients) revealed that P2 amplitude was significantly increased at Fz electrode following treatment with TPM. Statistical non-parametric map of sLORETA between pre- and post-TPM ERPs revealed that current density of P200 component was significantly reduced by TPM in bilateral parieto-occipital, temporolimbic and dorsolateral right prefrontal regions. Conclusions: Our findings suggest that TPM affects selective brain regions which may be related to cognitive side effects. Significance: Source localisation of ERPs can be helpful in identifying target brain regions for the cognitive side effects of anti-epileptic drugs.
Original language | English |
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Pages (from-to) | 1494-1501 |
Number of pages | 8 |
Journal | Clinical Neurophysiology |
Volume | 121 |
Issue number | 9 |
DOIs | |
Publication status | Published - 2010 Sept |
Keywords
- Cognitive function
- Event-related potential (ERP)
- Source localisation
- Standardised low-resolution electromagnetic tomography (sLORETA)
- Topiramate
ASJC Scopus subject areas
- Sensory Systems
- Neurology
- Clinical Neurology
- Physiology (medical)