Colonic mucosal immune activation in mice with ovalbumin-induced allergic airway disease: Association between allergic airway disease and irritable bowel syndrome

Sanghyun Kim; Bora Keum; Junhyoung Byun; Byoungjae Kim; Kijeong Lee; Jiwoo Yeon; Jae Min Lee; Hyuk Soon Choi; Eun-Sun Kim; Yoon Tae Jeen; Hong Sik Lee; Hoon-Jai Chun; Taehoon Kim

doi:10.3390/ijms23010181

Colonic mucosal immune activation in mice with ovalbumin-induced allergic airway disease: Association between allergic airway disease and irritable bowel syndrome

Sanghyun Kim, Bora Keum, Junhyoung Byun, Byoungjae Kim, Kijeong Lee, Jiwoo Yeon, Jae Min Lee, Hyuk Soon Choi, Eun-Sun Kim, Yoon Tae Jeen, Hong Sik Lee, Hoon-Jai Chun, Taehoon Kim

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.

Original language	English
Article number	181
Journal	International journal of molecular sciences
Volume	23
Issue number	1
DOIs	https://doi.org/10.3390/ijms23010181
Publication status	Published - 2022 Jan 1

Bibliographical note

Funding Information:
Funding: This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and Ministry of Science, ICT and Future Planning, grant number NRF-2020R1A2C1006398; the Ministry of Science and ICT (MSIT), Korea, under the ICT Creative Consilience program, grant number IITP-2021-0-01819, supervised by the Institute for Information & communications Technology Planning & Evaluation (IITP). This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O2106591).

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).

Keywords

Allergic airway diseases
Irritable bowel syndrome
Mast cells
Salbutamol

ASJC Scopus subject areas

Catalysis
Molecular Biology
Spectroscopy
Computer Science Applications
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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10.3390/ijms23010181

Cite this

Kim, S., Keum, B., Byun, J., Kim, B., Lee, K., Yeon, J., Lee, J. M., Choi, H. S., Kim, E.-S., Jeen, Y. T., Lee, H. S., Chun, H.-J., & Kim, T. (2022). Colonic mucosal immune activation in mice with ovalbumin-induced allergic airway disease: Association between allergic airway disease and irritable bowel syndrome. International journal of molecular sciences, 23(1), Article 181. https://doi.org/10.3390/ijms23010181

Kim, S, Keum, B, Byun, J, Kim, B, Lee, K, Yeon, J, Lee, JM, Choi, HS, Kim, E-S, Jeen, YT, Lee, HS, Chun, H-J & Kim, T 2022, 'Colonic mucosal immune activation in mice with ovalbumin-induced allergic airway disease: Association between allergic airway disease and irritable bowel syndrome', International journal of molecular sciences, vol. 23, no. 1, 181. https://doi.org/10.3390/ijms23010181

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abstract = "Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.",

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author = "Sanghyun Kim and Bora Keum and Junhyoung Byun and Byoungjae Kim and Kijeong Lee and Jiwoo Yeon and Lee, {Jae Min} and Choi, {Hyuk Soon} and Eun-Sun Kim and Jeen, {Yoon Tae} and Lee, {Hong Sik} and Hoon-Jai Chun and Taehoon Kim",

note = "Funding Information: Funding: This research was supported by the Basic Science Research Program, National Research Foundation of Korea, funded by the Ministry of Science and Technology and Ministry of Science, ICT and Future Planning, grant number NRF-2020R1A2C1006398; the Ministry of Science and ICT (MSIT), Korea, under the ICT Creative Consilience program, grant number IITP-2021-0-01819, supervised by the Institute for Information & communications Technology Planning & Evaluation (IITP). This research was supported by a grant of Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. O2106591). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).",

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AU - Lee, Kijeong

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AU - Lee, Jae Min

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AU - Kim, Eun-Sun

AU - Jeen, Yoon Tae

AU - Lee, Hong Sik

AU - Chun, Hoon-Jai

AU - Kim, Taehoon

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N2 - Recent studies on the pathophysiology of irritable bowel syndrome (IBS) have focused on the role of mast cells (MCs) in intestinal mucosal immunity. A link between allergic airway diseases (AADs) and IBS has been suggested because both diseases have similar pathophysiology. We aimed to investigate whether the induction of AAD in mice could lead to inflammation of the colonic mucosa, similar to IBS. We also evaluated whether this inflammatory response could be suppressed by administering a therapeutic agent. Mice were divided into three groups: control, AAD-induced, and salbutamol-treated. An AAD mouse model was established by intraperitoneal injection and nasal challenge with ovalbumin. Mice with AAD were intranasally administered salbutamol. Analyses of cytokine levels, MC count, and tryptase levels in the intestinal mucosa were performed to compare the changes in inflammatory responses among the three groups. Inflammation was observed in the intestinal mucosa of mice in the AAD group. This inflammation in AAD mice was suppressed after salbutamol treatment. Our study demonstrates that AAD induces an inflammatory response similar to that in IBS, suggesting a possible association between IBS and AADs. In patients with IBS with such allergic components, salbutamol may have the potential to alleviate the inflammatory response.

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Colonic mucosal immune activation in mice with ovalbumin-induced allergic airway disease: Association between allergic airway disease and irritable bowel syndrome

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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