Colorimetric SNP Genotyping Based on Allele-Specific PCR by Using a Thiol-Labeled Primer

Ye Lim Jung; Cheulhee Jung; Harshala Parab; Dae Yeon Cho; Hyun Gyu Park

doi:10.1002/cbic.201100098

Colorimetric SNP Genotyping Based on Allele-Specific PCR by Using a Thiol-Labeled Primer

Ye Lim Jung, Cheulhee Jung, Harshala Parab, Dae Yeon Cho, Hyun Gyu Park

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Red gold/blue gold: A highly convenient colorimetric method for the identification of single-nucleotide polymorphism was developed by utilizing gold nanoparticles and an allele-specific polymerase chain reaction. Its diagnostic capability was successfully demonstrated by correctly identifying various mutations in the BRCA1 gene.

Original language	English
Pages (from-to)	1387-1390
Number of pages	4
Journal	ChemBioChem
Volume	12
Issue number	9
DOIs	https://doi.org/10.1002/cbic.201100098
Publication status	Published - 2011 Jun 14
Externally published	Yes

Keywords

BRCA
Gold
Nanoparticles
Polymerase chain reaction
Single nucleotide polymorphism
Thiolated primer

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Organic Chemistry

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10.1002/cbic.201100098

Cite this

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title = "Colorimetric SNP Genotyping Based on Allele-Specific PCR by Using a Thiol-Labeled Primer",

abstract = "Red gold/blue gold: A highly convenient colorimetric method for the identification of single-nucleotide polymorphism was developed by utilizing gold nanoparticles and an allele-specific polymerase chain reaction. Its diagnostic capability was successfully demonstrated by correctly identifying various mutations in the BRCA1 gene.",

keywords = "BRCA, Gold, Nanoparticles, Polymerase chain reaction, Single nucleotide polymorphism, Thiolated primer",

author = "Jung, {Ye Lim} and Cheulhee Jung and Harshala Parab and Cho, {Dae Yeon} and Park, {Hyun Gyu}",

year = "2011",

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AU - Jung, Ye Lim

AU - Jung, Cheulhee

AU - Parab, Harshala

AU - Cho, Dae Yeon

AU - Park, Hyun Gyu

PY - 2011/6/14

Y1 - 2011/6/14

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AB - Red gold/blue gold: A highly convenient colorimetric method for the identification of single-nucleotide polymorphism was developed by utilizing gold nanoparticles and an allele-specific polymerase chain reaction. Its diagnostic capability was successfully demonstrated by correctly identifying various mutations in the BRCA1 gene.

KW - BRCA

KW - Gold

KW - Nanoparticles

KW - Polymerase chain reaction

KW - Single nucleotide polymorphism

KW - Thiolated primer

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Colorimetric SNP Genotyping Based on Allele-Specific PCR by Using a Thiol-Labeled Primer

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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