TY - JOUR
T1 - Combination of statin and ezetimibe versus statin monotherapy on cardiovascular disease and type 2 diabetes incidence among adults with impaired fasting glucose
T2 - A propensity-matched nationwide cohort study
AU - Lee, You Bin
AU - Kim, Bongsung
AU - Han, Kyungdo
AU - Kim, Jung A.
AU - Roh, Eun
AU - Hong, So Hyeon
AU - Choi, Kyung Mook
AU - Baik, Sei-Hyun
AU - Yoo, Hye Jin
N1 - Funding Information:
This study was supported by the 2019 big data analysis grant from the Korean Society of Lipid and Atherosclerosis. The funding agency had no role in the design, collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication.
Publisher Copyright:
© 2021 The Korean Society of Lipid and Atherosclerosis.
PY - 2021/9
Y1 - 2021/9
N2 - Objective: We investigated the effects of statin-ezetimibe combination therapy compared with statin-only treatment on the hazard of incident type 2 diabetes (T2D), myocardial infarction (MI), and stroke among adults with impaired fasting glucose (IFG) in a real-world setting. Methods: The Korean National Health Insurance Service datasets from 2002 to 2017 were used for this propensity-matched nationwide cohort study. Among 56,633 IFG patients without baseline cardiovascular disease (CVD) and/or T2D who initiated statin therapy with or without ezetimibe, 1,155 with statin-ezetimibe combination therapy were matched based on a propensity score at a 1:5 ratio with 5,775 patients who received statin monotherapy. The hazards of T2D, MI, and stroke were compared between these treatment groups. Results: The incidence rate per 1,000 person-years was 19.62 (statin monotherapy group) and 21.02 (combined treatment group) for T2D, 1.53 (statin monotherapy group) and 1.70 (combined treatment group) for MI, and 1.99 (statin monotherapy group) and 2.06 (combined treatment group) for stroke. The hazards of T2D, MI, and stroke were not significantly different between the statin monotherapy group and the statin-ezetimibe combination therapy group. Conclusion: The combination of ezetimibe in addition to statin treatment was not associated with a significantly different risk of T2D and CVDs compared with statin monotherapy in Korean adults with IFG.
AB - Objective: We investigated the effects of statin-ezetimibe combination therapy compared with statin-only treatment on the hazard of incident type 2 diabetes (T2D), myocardial infarction (MI), and stroke among adults with impaired fasting glucose (IFG) in a real-world setting. Methods: The Korean National Health Insurance Service datasets from 2002 to 2017 were used for this propensity-matched nationwide cohort study. Among 56,633 IFG patients without baseline cardiovascular disease (CVD) and/or T2D who initiated statin therapy with or without ezetimibe, 1,155 with statin-ezetimibe combination therapy were matched based on a propensity score at a 1:5 ratio with 5,775 patients who received statin monotherapy. The hazards of T2D, MI, and stroke were compared between these treatment groups. Results: The incidence rate per 1,000 person-years was 19.62 (statin monotherapy group) and 21.02 (combined treatment group) for T2D, 1.53 (statin monotherapy group) and 1.70 (combined treatment group) for MI, and 1.99 (statin monotherapy group) and 2.06 (combined treatment group) for stroke. The hazards of T2D, MI, and stroke were not significantly different between the statin monotherapy group and the statin-ezetimibe combination therapy group. Conclusion: The combination of ezetimibe in addition to statin treatment was not associated with a significantly different risk of T2D and CVDs compared with statin monotherapy in Korean adults with IFG.
KW - Cardiovascular diseases
KW - Ezetimibe
KW - Prediabetic state
KW - Statin
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85118496636&partnerID=8YFLogxK
U2 - 10.12997/JLA.2021.10.3.303
DO - 10.12997/JLA.2021.10.3.303
M3 - Article
AN - SCOPUS:85118496636
SN - 2287-2892
VL - 10
SP - 303
EP - 312
JO - Journal of Lipid and Atherosclerosis
JF - Journal of Lipid and Atherosclerosis
IS - 3
ER -
