Combination Treatment with Photodynamic Therapy and Laser Ablation in Breast Cancer: An Animal Model Study

Jeeyeon Lee; Ho Yong Park; Wan Wook Kim; Ji Yun Jeong; Yong Deok Lee; Mi Hwa Choi; Sehoon Kim; Ji Young Park; Jin Hyang Jung

doi:10.1089/pho.2017.4291

Combination Treatment with Photodynamic Therapy and Laser Ablation in Breast Cancer: An Animal Model Study

Jeeyeon Lee, Ho Yong Park, Wan Wook Kim, Ji Yun Jeong, Yong Deok Lee, Mi Hwa Choi, Sehoon Kim, Ji Young Park, Jin Hyang Jung

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Purpose: Minimally invasive treatments for early breast cancer have been reported. The objective of this study was to evaluate and compare two such treatments, laser ablation and photodynamic therapy (PDT), regarding their therapeutic efficacy for breast cancer. Methods: Breast tumors were induced in 12 mice models. The treatment options were classified into four groups: control group (without any treatment, A), group treated only with laser ablation (B), group treated only with PDT (C), and group treated with the combination of laser ablation followed by PDT (D). The treatment effects were compared among these groups. Results: Among the groups, the group D underwent the most effective treatment for breast cancer. Not only were the breast cancer cells necrotized by laser ablation, but the tumor margin was also managed by PDT. Conclusions: The treatment method combining laser ablation and PDT showed superior results to single treatment techniques using just one of these approaches.

Original language	English
Pages (from-to)	505-512
Number of pages	8
Journal	Photomedicine and Laser Surgery
Volume	35
Issue number	9
DOIs	https://doi.org/10.1089/pho.2017.4291
Publication status	Published - 2017 Sept

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Government of the Republic of Korea (MEST; No. 2009-0091573). And this research was also supported by a National Research Foundation (NRF) grant funded by the Government of the Republic of Korea (2014R1A5A2009242), a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1420040), IN-NOPOLIS Foundation grant funded by the Government of the Republic of Korea (MSIP; No. 2015DG0004), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0636).

Publisher Copyright:
© Copyright 2017, Mary Ann Liebert, Inc. 2017.

Keywords

breast carcinoma
laser ablation
photodynamic therapy

ASJC Scopus subject areas

Biomedical Engineering
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/pho.2017.4291

Cite this

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title = "Combination Treatment with Photodynamic Therapy and Laser Ablation in Breast Cancer: An Animal Model Study",

abstract = "Purpose: Minimally invasive treatments for early breast cancer have been reported. The objective of this study was to evaluate and compare two such treatments, laser ablation and photodynamic therapy (PDT), regarding their therapeutic efficacy for breast cancer. Methods: Breast tumors were induced in 12 mice models. The treatment options were classified into four groups: control group (without any treatment, A), group treated only with laser ablation (B), group treated only with PDT (C), and group treated with the combination of laser ablation followed by PDT (D). The treatment effects were compared among these groups. Results: Among the groups, the group D underwent the most effective treatment for breast cancer. Not only were the breast cancer cells necrotized by laser ablation, but the tumor margin was also managed by PDT. Conclusions: The treatment method combining laser ablation and PDT showed superior results to single treatment techniques using just one of these approaches.",

keywords = "breast carcinoma, laser ablation, photodynamic therapy",

author = "Jeeyeon Lee and Park, {Ho Yong} and Kim, {Wan Wook} and Jeong, {Ji Yun} and Lee, {Yong Deok} and Choi, {Mi Hwa} and Sehoon Kim and Park, {Ji Young} and Jung, {Jin Hyang}",

note = "Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Government of the Republic of Korea (MEST; No. 2009-0091573). And this research was also supported by a National Research Foundation (NRF) grant funded by the Government of the Republic of Korea (2014R1A5A2009242), a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1420040), IN-NOPOLIS Foundation grant funded by the Government of the Republic of Korea (MSIP; No. 2015DG0004), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0636). Publisher Copyright: {\textcopyright} Copyright 2017, Mary Ann Liebert, Inc. 2017.",

year = "2017",

month = sep,

doi = "10.1089/pho.2017.4291",

language = "English",

volume = "35",

pages = "505--512",

journal = "Photomedicine and Laser Surgery",

issn = "1549-5418",

publisher = "Mary Ann Liebert Inc.",

number = "9",

}

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T1 - Combination Treatment with Photodynamic Therapy and Laser Ablation in Breast Cancer

T2 - An Animal Model Study

AU - Lee, Jeeyeon

AU - Park, Ho Yong

AU - Kim, Wan Wook

AU - Jeong, Ji Yun

AU - Lee, Yong Deok

AU - Choi, Mi Hwa

AU - Kim, Sehoon

AU - Park, Ji Young

AU - Jung, Jin Hyang

N1 - Funding Information: This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Government of the Republic of Korea (MEST; No. 2009-0091573). And this research was also supported by a National Research Foundation (NRF) grant funded by the Government of the Republic of Korea (2014R1A5A2009242), a grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1420040), IN-NOPOLIS Foundation grant funded by the Government of the Republic of Korea (MSIP; No. 2015DG0004), and a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI16C0636). Publisher Copyright: © Copyright 2017, Mary Ann Liebert, Inc. 2017.

PY - 2017/9

Y1 - 2017/9

N2 - Purpose: Minimally invasive treatments for early breast cancer have been reported. The objective of this study was to evaluate and compare two such treatments, laser ablation and photodynamic therapy (PDT), regarding their therapeutic efficacy for breast cancer. Methods: Breast tumors were induced in 12 mice models. The treatment options were classified into four groups: control group (without any treatment, A), group treated only with laser ablation (B), group treated only with PDT (C), and group treated with the combination of laser ablation followed by PDT (D). The treatment effects were compared among these groups. Results: Among the groups, the group D underwent the most effective treatment for breast cancer. Not only were the breast cancer cells necrotized by laser ablation, but the tumor margin was also managed by PDT. Conclusions: The treatment method combining laser ablation and PDT showed superior results to single treatment techniques using just one of these approaches.

AB - Purpose: Minimally invasive treatments for early breast cancer have been reported. The objective of this study was to evaluate and compare two such treatments, laser ablation and photodynamic therapy (PDT), regarding their therapeutic efficacy for breast cancer. Methods: Breast tumors were induced in 12 mice models. The treatment options were classified into four groups: control group (without any treatment, A), group treated only with laser ablation (B), group treated only with PDT (C), and group treated with the combination of laser ablation followed by PDT (D). The treatment effects were compared among these groups. Results: Among the groups, the group D underwent the most effective treatment for breast cancer. Not only were the breast cancer cells necrotized by laser ablation, but the tumor margin was also managed by PDT. Conclusions: The treatment method combining laser ablation and PDT showed superior results to single treatment techniques using just one of these approaches.

KW - breast carcinoma

KW - laser ablation

KW - photodynamic therapy

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DO - 10.1089/pho.2017.4291

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SN - 1549-5418

VL - 35

SP - 505

EP - 512

JO - Photomedicine and Laser Surgery

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IS - 9

ER -

Combination Treatment with Photodynamic Therapy and Laser Ablation in Breast Cancer: An Animal Model Study

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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