Combinatorial dansyl library and its applications to pH-responsive probes

Seong Cheol Hong; Dhiraj P. Murale; Jun Seok Lee

doi:10.2174/1386207319666160408150203

Combinatorial dansyl library and its applications to pH-responsive probes

Seong Cheol Hong, Dhiraj P. Murale, Jun Seok Lee

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.

Original language	English
Pages (from-to)	347-352
Number of pages	6
Journal	Combinatorial Chemistry and High Throughput Screening
Volume	19
Issue number	5
DOIs	https://doi.org/10.2174/1386207319666160408150203
Publication status	Published - 2016 Jun 1
Externally published	Yes

Bibliographical note

Publisher Copyright:
©2016 Bentham Science Publishers.

Keywords

Combinatorial chemistry
Dansyl chloride
PH sensor.

ASJC Scopus subject areas

Drug Discovery
Computer Science Applications
Organic Chemistry

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10.2174/1386207319666160408150203

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title = "Combinatorial dansyl library and its applications to pH-responsive probes",

abstract = "Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.",

keywords = "Combinatorial chemistry, Dansyl chloride, PH sensor.",

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AU - Hong, Seong Cheol

AU - Murale, Dhiraj P.

AU - Lee, Jun Seok

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Y1 - 2016/6/1

N2 - Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.

AB - Herein, we report the first 48-membered, dansyl-based, combinatorial fluorescent library. From the electronic and structural properties of the probes, we analyzed their optical properties and chemical yields, with an average of 49 %. The molecules were examined for their pH responses, and DS-2 and DS-45 showed blue-shifts, whereas DS-7 and DS-40 showed red-shifts in wavelength with increasing pH. Finally, cell permeability was investigated by treating SNU-2292 cells. Our results demonstrate the potential application of this library in biosensors, bio-imaging and pH indicators.

KW - Combinatorial chemistry

KW - Dansyl chloride

KW - PH sensor.

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JO - Combinatorial Chemistry and High Throughput Screening

JF - Combinatorial Chemistry and High Throughput Screening

IS - 5

ER -

Combinatorial dansyl library and its applications to pH-responsive probes

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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