Combined adenosquamous and large cell neuroendocrine carcinoma of the gallbladder

Jiyoon Jung; Yang Seok Chae; Chul Hwan Kim; Youngseok Lee; Jeong Hyeon Lee; Dong Sik Kim; Young Dong Yu; Joo Young Kim

doi:10.4132/jptm.2017.08.20

Combined adenosquamous and large cell neuroendocrine carcinoma of the gallbladder

Jiyoon Jung, Yang Seok Chae, Chul Hwan Kim, Youngseok Lee, Jeong Hyeon Lee, Dong Sik Kim, Young Dong Yu, Joo Young Kim

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3 × 4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.

Original language	English
Pages (from-to)	121-125
Number of pages	5
Journal	Journal of Pathology and Translational Medicine
Volume	52
Issue number	2
DOIs	https://doi.org/10.4132/jptm.2017.08.20
Publication status	Published - 2018 Mar 1

Keywords

Adenosquamous
Carcinoma
Gallbladder
Large cell neuroendocrine carcinoma
Prognosis

ASJC Scopus subject areas

Pathology and Forensic Medicine
Histology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4132/jptm.2017.08.20

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title = "Combined adenosquamous and large cell neuroendocrine carcinoma of the gallbladder",

abstract = "Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3 × 4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.",

keywords = "Adenosquamous, Carcinoma, Gallbladder, Large cell neuroendocrine carcinoma, Prognosis",

author = "Jiyoon Jung and Chae, {Yang Seok} and Kim, {Chul Hwan} and Youngseok Lee and Lee, {Jeong Hyeon} and Kim, {Dong Sik} and Yu, {Young Dong} and Kim, {Joo Young}",

note = "Funding Information: This work was supported by the Italian Ministry of Education and University (No. 2017FJSM9S). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: {\textcopyright} 2018 The Korean Society of Pathologists/The Korean Society for Cytopathology.",

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doi = "10.4132/jptm.2017.08.20",

language = "English",

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T1 - Combined adenosquamous and large cell neuroendocrine carcinoma of the gallbladder

AU - Jung, Jiyoon

AU - Chae, Yang Seok

AU - Kim, Chul Hwan

AU - Lee, Youngseok

AU - Lee, Jeong Hyeon

AU - Kim, Dong Sik

AU - Yu, Young Dong

AU - Kim, Joo Young

N1 - Funding Information: This work was supported by the Italian Ministry of Education and University (No. 2017FJSM9S). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2018 The Korean Society of Pathologists/The Korean Society for Cytopathology.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3 × 4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.

AB - Large cell neuroendocrine carcinoma (LCNEC) of the gallbladder is extremely rare and usually combined with other type of malignancy, mostly adenocarcinoma. We report an unusual case of combined adenosquamous carcinoma and LCNEC of the gallbladder in a 54-year-old woman. A radical cholecystectomy specimen revealed a 4.3 × 4.0 cm polypoid mass in the fundus with infiltration of adjacent liver parenchyma. Microscopically, the tumor consisted of two distinct components. Adenosquamous carcinoma was predominant and abrupt transition from adenocarcinoma to squamous cell carcinoma was observed. LCNEC showed round cells with large, vesicular nuclei, abundant mitotic figures, and occasional pseudorosette formation. The patient received adjuvant chemotherapy. However, multiple liver metastases were identified at 3-month follow-up. Metastatic nodules were composed of LCNEC and squamous cell carcinoma components. Detecting LCNEC component is important in gallbladder cancer, because the tumor may require a different chemotherapy regimen and show early metastasis and poor prognosis.

KW - Adenosquamous

KW - Carcinoma

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KW - Large cell neuroendocrine carcinoma

KW - Prognosis

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Combined adenosquamous and large cell neuroendocrine carcinoma of the gallbladder

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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