Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12

Seo Yun Tong; Mi Kyung Kim; Jae Kwan Lee; Jong Min Lee; Sang Woon Choi; Simonetta Friso; Eun Seop Song; Kwang Beom Lee; Jung Pil Lee

doi:10.1007/s10552-010-9675-6

Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12

Seo Yun Tong, Mi Kyung Kim, Jae Kwan Lee, Jong Min Lee, Sang Woon Choi, Simonetta Friso, Eun Seop Song, Kwang Beom Lee, Jung Pil Lee

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Objective: We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: This multicenter case-control study enrolled 927 Korean women (440 controls, 165 patients with CIN 1, 167 patients with CIN 2/3, and 155 patients with cervical cancer, aged 20-75 years). Results: Patients with cervical cancer had significantly lower median serum folate and vitamin B12 concentrations vs. controls. Higher serum folate was significantly associated with lower cervical cancer risk (p for linear trend = 0.0058) with a trend for a lower CIN risk after multivariate adjustment. Low folate and the MTHFR 677 C > T variant were associated with a higher risk for CIN2/3 and cervical cancer vs. wild-type or heterozygous genotypes with high folate [OR, 2.39 (1.18-4.85) and 3.19 (1.43-7.13)]. Low vitamin B12 and the MTHFR 677 C > T variant also were associated with a higher risk for CIN 2/3 and cervical cancers [OR, 2.52 (1.17-5.42) and 2.40 (1-5.73)] vs. wild-type or heterozygous status with high vitamin levels. Conclusion: Serum folate concentration is inversely associated with the risk of cervical cancer, and the MTHFR variant genotype may increase CIN and cervical cancer risk in women with low folate or vitamin B12 status.

Original language	English
Pages (from-to)	63-72
Number of pages	10
Journal	Cancer Causes and Control
Volume	22
Issue number	1
DOIs	https://doi.org/10.1007/s10552-010-9675-6
Publication status	Published - 2011 Jan
Externally published	Yes

Bibliographical note

Funding Information:
Acknowledgments This work was supported in part by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (R01-2006-000-10621-0). The authors’ contributions to this work were as follows: KMK designed the study and obtained funding; ST and SHS drafted the manuscript; KMK, SWC, and SF contributed to the interpretation of the results and manuscript preparation; and JML, JKL, ESS, KBL, and JPL recruited subjects and collected the data. All authors approved the final manuscript. None of the authors report any conflict of interest.

Keywords

Cervical cancer
Cervical intraepithelial neoplasia
Folate
Genetic polymorphisms
Methylenetetrahydrofolate reductase
Vitamin B12

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10552-010-9675-6

Cite this

Tong, S. Y., Kim, M. K., Lee, J. K., Lee, J. M., Choi, S. W., Friso, S., Song, E. S., Lee, K. B., & Lee, J. P. (2011). Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. Cancer Causes and Control, 22(1), 63-72. https://doi.org/10.1007/s10552-010-9675-6

Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12. / Tong, Seo Yun; Kim, Mi Kyung; Lee, Jae Kwan et al.
In: Cancer Causes and Control, Vol. 22, No. 1, 01.2011, p. 63-72.

Research output: Contribution to journal › Article › peer-review

Tong, SY, Kim, MK, Lee, JK, Lee, JM, Choi, SW, Friso, S, Song, ES, Lee, KB & Lee, JP 2011, 'Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12', Cancer Causes and Control, vol. 22, no. 1, pp. 63-72. https://doi.org/10.1007/s10552-010-9675-6

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title = "Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12",

abstract = "Objective: We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: This multicenter case-control study enrolled 927 Korean women (440 controls, 165 patients with CIN 1, 167 patients with CIN 2/3, and 155 patients with cervical cancer, aged 20-75 years). Results: Patients with cervical cancer had significantly lower median serum folate and vitamin B12 concentrations vs. controls. Higher serum folate was significantly associated with lower cervical cancer risk (p for linear trend = 0.0058) with a trend for a lower CIN risk after multivariate adjustment. Low folate and the MTHFR 677 C > T variant were associated with a higher risk for CIN2/3 and cervical cancer vs. wild-type or heterozygous genotypes with high folate [OR, 2.39 (1.18-4.85) and 3.19 (1.43-7.13)]. Low vitamin B12 and the MTHFR 677 C > T variant also were associated with a higher risk for CIN 2/3 and cervical cancers [OR, 2.52 (1.17-5.42) and 2.40 (1-5.73)] vs. wild-type or heterozygous status with high vitamin levels. Conclusion: Serum folate concentration is inversely associated with the risk of cervical cancer, and the MTHFR variant genotype may increase CIN and cervical cancer risk in women with low folate or vitamin B12 status.",

keywords = "Cervical cancer, Cervical intraepithelial neoplasia, Folate, Genetic polymorphisms, Methylenetetrahydrofolate reductase, Vitamin B12",

author = "Tong, {Seo Yun} and Kim, {Mi Kyung} and Lee, {Jae Kwan} and Lee, {Jong Min} and Choi, {Sang Woon} and Simonetta Friso and Song, {Eun Seop} and Lee, {Kwang Beom} and Lee, {Jung Pil}",

note = "Funding Information: Acknowledgments This work was supported in part by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (R01-2006-000-10621-0). The authors{\textquoteright} contributions to this work were as follows: KMK designed the study and obtained funding; ST and SHS drafted the manuscript; KMK, SWC, and SF contributed to the interpretation of the results and manuscript preparation; and JML, JKL, ESS, KBL, and JPL recruited subjects and collected the data. All authors approved the final manuscript. None of the authors report any conflict of interest.",

year = "2011",

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doi = "10.1007/s10552-010-9675-6",

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pages = "63--72",

journal = "Cancer Causes and Control",

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T1 - Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12

AU - Tong, Seo Yun

AU - Kim, Mi Kyung

AU - Lee, Jae Kwan

AU - Lee, Jong Min

AU - Choi, Sang Woon

AU - Friso, Simonetta

AU - Song, Eun Seop

AU - Lee, Kwang Beom

AU - Lee, Jung Pil

N1 - Funding Information: Acknowledgments This work was supported in part by a Korea Science and Engineering Foundation (KOSEF) grant funded by the Korean government (MOST) (R01-2006-000-10621-0). The authors’ contributions to this work were as follows: KMK designed the study and obtained funding; ST and SHS drafted the manuscript; KMK, SWC, and SF contributed to the interpretation of the results and manuscript preparation; and JML, JKL, ESS, KBL, and JPL recruited subjects and collected the data. All authors approved the final manuscript. None of the authors report any conflict of interest.

PY - 2011/1

Y1 - 2011/1

N2 - Objective: We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: This multicenter case-control study enrolled 927 Korean women (440 controls, 165 patients with CIN 1, 167 patients with CIN 2/3, and 155 patients with cervical cancer, aged 20-75 years). Results: Patients with cervical cancer had significantly lower median serum folate and vitamin B12 concentrations vs. controls. Higher serum folate was significantly associated with lower cervical cancer risk (p for linear trend = 0.0058) with a trend for a lower CIN risk after multivariate adjustment. Low folate and the MTHFR 677 C > T variant were associated with a higher risk for CIN2/3 and cervical cancer vs. wild-type or heterozygous genotypes with high folate [OR, 2.39 (1.18-4.85) and 3.19 (1.43-7.13)]. Low vitamin B12 and the MTHFR 677 C > T variant also were associated with a higher risk for CIN 2/3 and cervical cancers [OR, 2.52 (1.17-5.42) and 2.40 (1-5.73)] vs. wild-type or heterozygous status with high vitamin levels. Conclusion: Serum folate concentration is inversely associated with the risk of cervical cancer, and the MTHFR variant genotype may increase CIN and cervical cancer risk in women with low folate or vitamin B12 status.

AB - Objective: We evaluated associations between folate, vitamin B12, and the methylenetetrahydrofolate reductase (MTHFR) gene, and risk of cervical intraepithelial neoplasia (CIN) and cervical cancer. Methods: This multicenter case-control study enrolled 927 Korean women (440 controls, 165 patients with CIN 1, 167 patients with CIN 2/3, and 155 patients with cervical cancer, aged 20-75 years). Results: Patients with cervical cancer had significantly lower median serum folate and vitamin B12 concentrations vs. controls. Higher serum folate was significantly associated with lower cervical cancer risk (p for linear trend = 0.0058) with a trend for a lower CIN risk after multivariate adjustment. Low folate and the MTHFR 677 C > T variant were associated with a higher risk for CIN2/3 and cervical cancer vs. wild-type or heterozygous genotypes with high folate [OR, 2.39 (1.18-4.85) and 3.19 (1.43-7.13)]. Low vitamin B12 and the MTHFR 677 C > T variant also were associated with a higher risk for CIN 2/3 and cervical cancers [OR, 2.52 (1.17-5.42) and 2.40 (1-5.73)] vs. wild-type or heterozygous status with high vitamin levels. Conclusion: Serum folate concentration is inversely associated with the risk of cervical cancer, and the MTHFR variant genotype may increase CIN and cervical cancer risk in women with low folate or vitamin B12 status.

KW - Cervical cancer

KW - Cervical intraepithelial neoplasia

KW - Folate

KW - Genetic polymorphisms

KW - Methylenetetrahydrofolate reductase

KW - Vitamin B12

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Common polymorphisms in methylenetetrahydrofolate reductase gene are associated with risks of cervical intraepithelial neoplasia and cervical cancer in women with low serum folate and vitamin B12

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this