Comparative gene expression profiling reveals the mechanisms of axon regeneration

Jinyoung Lee, Yongcheol Cho

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)


Axons are vulnerable to injury, potentially leading to degeneration or neuronal death. While neurons in the central nervous system fail to regenerate, neurons in the peripheral nervous system are known to regenerate. Since it has been shown that injury-response signal transduction is mediated by gene expression changes, expression profiling is a useful tool to understand the molecular mechanisms of regeneration. Axon regeneration is regulated by injury-responsive genes induced in both neurons and their surrounding non-neuronal cells. Thus, an experimental setup for the comparative analysis between regenerative and nonregenerative conditions is essential to identify ideal targets for the promotion of regeneration-associated genes and to understand the mechanisms of axon regeneration. Here, we review the original research that shows the key factors regulating axon regeneration, in particular by using comparative gene expression profiling in diverse systems.

Original languageEnglish
Pages (from-to)4786-4797
Number of pages12
JournalFEBS Journal
Issue number16
Publication statusPublished - 2021 Aug

Bibliographical note

Funding Information:
We thank Zehra Alibasic, Yeonsoo Oh, Eun Su Jang, and Minki Hong (Korea University) for critical reading of the manuscript. This work was supported by the Samsung Research Funding & Incubation Center of Samsung Electronics under Project Number SRFC‐MA1802‐07.

Publisher Copyright:
© 2020 Federation of European Biochemical Societies.


  • axon regeneration
  • comparative analysis
  • differential gene expression
  • gene expression profiling
  • nerve injury
  • transcriptome

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology


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