Comparison of additional minocycline versus iodopovidone pleurodesis during video-assisted thoracoscopic bleb resection for primary spontaneous pneumothorax: A propensity score-matched analysis

Kang Hoon Lee, Bo Taek Kim, Hyun Koo Kim, Kook Nam Han, Young Ho Choi

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    5 Citations (Scopus)

    Abstract

    Background: The optimal chemical agent for additional pleurodesis during video-assisted thoracoscopic surgery (VATS) bleb resection in primary spontaneous pneumothorax (PSP) remains controversial. We compared the efficacy and safety of iodopovidone with those of minocycline for additional chemical pleurodesis during VATS bleb resection. Methods: Of 332 patients who underwent VATS bleb resection, 299 patients diagnosed with PSP were enrolled in this study. The patients were divided into two groups according to the chemical agents used for additional pleurodesis (iodopovidone versus minocycline). Propensity score matching was performed on the basis of the preoperative clinical parameters. Postoperative complications, chest tube indwelling time, postoperative hospital stay, and recurrence rate were compared between the two groups. Results: The median duration of follow-up was 14 months (range, 1-94 months). After propensity score matching, 94 patients from the iodopovidone group and 94 patients from the minocycline group were matched. The perioperative outcomes, including fever, prolonged air-leak, prolonged-effusion, postoperative bed-side pleurodesis, and rehospitalization because of complications, were not significantly different between the two groups. However, the amount of drainage during the first two postoperative days, duration of chest tube indwelling, and duration of hospitalization were significantly shorter in the minocycline group (P<0.001). Conclusions: This study confirmed the safety of both minocycline and iodopovidone for additional pleurodesis. However, we carefully recommend minocycline over iodopovidone for pleurodesis because of faster postoperative recovery.

    Original languageEnglish
    Pages (from-to)5443-5448
    Number of pages6
    JournalJournal of Thoracic Disease
    Volume10
    Issue number9
    DOIs
    Publication statusPublished - 2018 Sept 1

    Bibliographical note

    Funding Information:
    Funding: This work was supported by a grant of the Korea

    Publisher Copyright:
    © 2018 Journal of Thoracic Disease. All rights reserved.

    Keywords

    • Iodopovidone
    • Minocycline
    • Pleurodesis
    • Pneumothorax
    • Video-assisted thoracoscopic surgery (VATS)

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine

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