Comparison of chest radiography, chest digital tomosynthesis and low dose MDCT to detect small ground-glass opacity nodules: an anthropomorphic chest phantom study

Kyung Won Doo; Eun Young Kang; Hwan Seok Yong; Soo Youn Ham; Ki Yeol Lee; Ji Yung Choo

doi:10.1007/s00330-014-3376-6

Comparison of chest radiography, chest digital tomosynthesis and low dose MDCT to detect small ground-glass opacity nodules: an anthropomorphic chest phantom study

Kyung Won Doo, Eun Young Kang, Hwan Seok Yong, Soo Youn Ham, Ki Yeol Lee, Ji Yung Choo

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Objectives: The purpose of this study was to evaluate the diagnostic performance of chest radiography (CXR), chest digital tomosynthesis (DT) and low dose multidetector computed tomography (LDCT) for the detection of small pulmonary ground-glass opacity (GGO) nodules, using an anthropomorphic chest phantom.

Methods: Artificial pulmonary nodules were placed in a phantom and a total of 40 samples of different nodule settings underwent CXR, DT and LDCT. The images were randomly read by three experienced chest radiologists. Free-response receiver-operating characteristics (FROC) were used.

Results: The figures of merit for the FROC curves averaged for the three observers were 0.41, 0.37 and 0.76 for CXR, DT and LDCT, respectively. FROC analyses revealed significantly better performance of LDCT over CXR or DT for the detection of GGO nodules (P < 0.05). The difference in detectability between CXR and DT was not statistically significant (P = 0.73).

Conclusion: The diagnostic performance of DT for the detection of pulmonary small GGO nodules was not significantly different from that of CXR, but LDCT performed significantly better than both CXR and DT. DT is not a suitable alternative to CT for small GGO nodule detection, and LDCT remains the method of choice for this purpose.

Key Points: • For GGO nodule detection, DT was not significantly different from CXR.

• DT is not a suitable alternative to CT for GGO nodule detection.

• LDCT is the method of choice for GGO nodule detection.

Original language	English
Pages (from-to)	3269-3276
Number of pages	8
Journal	European Radiology
Volume	24
Issue number	12
DOIs	https://doi.org/10.1007/s00330-014-3376-6
Publication status	Published - 2014 Nov 14
Externally published	Yes

Keywords

Computed tomography
Digital tomosynthesis
Pulmonary nodule
Radiography
Thoracic imaging

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1007/s00330-014-3376-6

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@article{6ea12496fe6e4f1694969101ce7b479d,

title = "Comparison of chest radiography, chest digital tomosynthesis and low dose MDCT to detect small ground-glass opacity nodules: an anthropomorphic chest phantom study",

abstract = "Objectives: The purpose of this study was to evaluate the diagnostic performance of chest radiography (CXR), chest digital tomosynthesis (DT) and low dose multidetector computed tomography (LDCT) for the detection of small pulmonary ground-glass opacity (GGO) nodules, using an anthropomorphic chest phantom.Methods: Artificial pulmonary nodules were placed in a phantom and a total of 40 samples of different nodule settings underwent CXR, DT and LDCT. The images were randomly read by three experienced chest radiologists. Free-response receiver-operating characteristics (FROC) were used.Results: The figures of merit for the FROC curves averaged for the three observers were 0.41, 0.37 and 0.76 for CXR, DT and LDCT, respectively. FROC analyses revealed significantly better performance of LDCT over CXR or DT for the detection of GGO nodules (P < 0.05). The difference in detectability between CXR and DT was not statistically significant (P = 0.73).Conclusion: The diagnostic performance of DT for the detection of pulmonary small GGO nodules was not significantly different from that of CXR, but LDCT performed significantly better than both CXR and DT. DT is not a suitable alternative to CT for small GGO nodule detection, and LDCT remains the method of choice for this purpose.Key Points: • For GGO nodule detection, DT was not significantly different from CXR.• DT is not a suitable alternative to CT for GGO nodule detection.• LDCT is the method of choice for GGO nodule detection.",

keywords = "Computed tomography, Digital tomosynthesis, Pulmonary nodule, Radiography, Thoracic imaging",

author = "Doo, {Kyung Won} and Kang, {Eun Young} and Yong, {Hwan Seok} and Ham, {Soo Youn} and Lee, {Ki Yeol} and Choo, {Ji Yung}",

note = "Funding Information: The scientific guarantor of this publication is Prof. Eun-Young Kang, Department of Radiology Korea University Guro Hospital, Korea University College of Medicine. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study has received funding by Korea University Medical College Radiology Grant (KUMCRG 03131). Ji Sung Lee (Biostatistical Consulting Unit, Soonchunhyang University Medical Center) kindly provided statistical advice for this manuscript. Institutional review board approval was not required because this was an experimental study based on a phantom. Methodology: experimental, performed at one institution. Publisher Copyright: {\textcopyright} 2014, European Society of Radiology.",

year = "2014",

month = nov,

day = "14",

doi = "10.1007/s00330-014-3376-6",

language = "English",

volume = "24",

pages = "3269--3276",

journal = "European Radiology",

issn = "0938-7994",

publisher = "Springer Verlag",

number = "12",

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TY - JOUR

T1 - Comparison of chest radiography, chest digital tomosynthesis and low dose MDCT to detect small ground-glass opacity nodules

T2 - an anthropomorphic chest phantom study

AU - Doo, Kyung Won

AU - Kang, Eun Young

AU - Yong, Hwan Seok

AU - Ham, Soo Youn

AU - Lee, Ki Yeol

AU - Choo, Ji Yung

N1 - Funding Information: The scientific guarantor of this publication is Prof. Eun-Young Kang, Department of Radiology Korea University Guro Hospital, Korea University College of Medicine. The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. This study has received funding by Korea University Medical College Radiology Grant (KUMCRG 03131). Ji Sung Lee (Biostatistical Consulting Unit, Soonchunhyang University Medical Center) kindly provided statistical advice for this manuscript. Institutional review board approval was not required because this was an experimental study based on a phantom. Methodology: experimental, performed at one institution. Publisher Copyright: © 2014, European Society of Radiology.

PY - 2014/11/14

Y1 - 2014/11/14

N2 - Objectives: The purpose of this study was to evaluate the diagnostic performance of chest radiography (CXR), chest digital tomosynthesis (DT) and low dose multidetector computed tomography (LDCT) for the detection of small pulmonary ground-glass opacity (GGO) nodules, using an anthropomorphic chest phantom.Methods: Artificial pulmonary nodules were placed in a phantom and a total of 40 samples of different nodule settings underwent CXR, DT and LDCT. The images were randomly read by three experienced chest radiologists. Free-response receiver-operating characteristics (FROC) were used.Results: The figures of merit for the FROC curves averaged for the three observers were 0.41, 0.37 and 0.76 for CXR, DT and LDCT, respectively. FROC analyses revealed significantly better performance of LDCT over CXR or DT for the detection of GGO nodules (P < 0.05). The difference in detectability between CXR and DT was not statistically significant (P = 0.73).Conclusion: The diagnostic performance of DT for the detection of pulmonary small GGO nodules was not significantly different from that of CXR, but LDCT performed significantly better than both CXR and DT. DT is not a suitable alternative to CT for small GGO nodule detection, and LDCT remains the method of choice for this purpose.Key Points: • For GGO nodule detection, DT was not significantly different from CXR.• DT is not a suitable alternative to CT for GGO nodule detection.• LDCT is the method of choice for GGO nodule detection.

AB - Objectives: The purpose of this study was to evaluate the diagnostic performance of chest radiography (CXR), chest digital tomosynthesis (DT) and low dose multidetector computed tomography (LDCT) for the detection of small pulmonary ground-glass opacity (GGO) nodules, using an anthropomorphic chest phantom.Methods: Artificial pulmonary nodules were placed in a phantom and a total of 40 samples of different nodule settings underwent CXR, DT and LDCT. The images were randomly read by three experienced chest radiologists. Free-response receiver-operating characteristics (FROC) were used.Results: The figures of merit for the FROC curves averaged for the three observers were 0.41, 0.37 and 0.76 for CXR, DT and LDCT, respectively. FROC analyses revealed significantly better performance of LDCT over CXR or DT for the detection of GGO nodules (P < 0.05). The difference in detectability between CXR and DT was not statistically significant (P = 0.73).Conclusion: The diagnostic performance of DT for the detection of pulmonary small GGO nodules was not significantly different from that of CXR, but LDCT performed significantly better than both CXR and DT. DT is not a suitable alternative to CT for small GGO nodule detection, and LDCT remains the method of choice for this purpose.Key Points: • For GGO nodule detection, DT was not significantly different from CXR.• DT is not a suitable alternative to CT for GGO nodule detection.• LDCT is the method of choice for GGO nodule detection.

KW - Computed tomography

KW - Digital tomosynthesis

KW - Pulmonary nodule

KW - Radiography

KW - Thoracic imaging

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DO - 10.1007/s00330-014-3376-6

M3 - Article

C2 - 25097138

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SN - 0938-7994

VL - 24

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EP - 3276

JO - European Radiology

JF - European Radiology

IS - 12

ER -

Comparison of chest radiography, chest digital tomosynthesis and low dose MDCT to detect small ground-glass opacity nodules: an anthropomorphic chest phantom study

Abstract

Keywords

ASJC Scopus subject areas

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