Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus

Seungcheol Lee; Chan Sam Moon; Donggeun Sul; Jiyoung Lee; Minyoung Bae; Youngki Hong; Min Lee; Seonyoung Choi; Richard Derby; Byung Jo Kim; Juhan Kim; Joon Sik Yoon; Lee Wolfer; Jaemin Kim; Joonho Wang; Sun Wook Hwang; Sang Heon Lee

doi:10.1016/j.clinbiochem.2009.06.017

Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus

Seungcheol Lee, Chan Sam Moon, Donggeun Sul, Jiyoung Lee, Minyoung Bae, Youngki Hong, Min Lee, Seonyoung Choi, Richard Derby, Byung Jo Kim, Juhan Kim, Joon Sik Yoon, Lee Wolfer, Jaemin Kim, Joonho Wang, Sun Wook Hwang, Sang Heon Lee

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

110 Citations (Scopus)

Abstract

Objectives: This study was conducted to investigate the expression of cytokines and growth factors in disc specimens obtained from patients with herniated nucleus pulposus (HNP) and degenerated disc disease (DDD). Design and methods: MRI and Western blot analyses were performed to evaluate the levels of disc degeneration and the expression levels of cytokines and growth factors. Results: The levels of TNF-α and IL-8 were significantly greater in the DDD group than in the HNP group, but no statistical differences were observed in the expression of IL-1β, IL-6 and IL-12 between the HNP and DDD groups. In addition, the expression of TGF β, VEGF and NGF was significantly higher in the DDD group than in the HNP group. Conclusion: The greater levels of cytokine and growth factor expression in the DDD group than in the HNP explain why discogenic patients usually have more severe back pain than patients with herniated discs.

Original language	English
Pages (from-to)	1504-1511
Number of pages	8
Journal	Clinical Biochemistry
Volume	42
Issue number	15
DOIs	https://doi.org/10.1016/j.clinbiochem.2009.06.017
Publication status	Published - 2009 Oct

Keywords

Cytokines
Degenerated disc disease (DDD)
Disc degeneration
Growth factors
Herniated nucleus pulposus (HNP)
MRI

ASJC Scopus subject areas

Clinical Biochemistry

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10.1016/j.clinbiochem.2009.06.017

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Lee, S., Moon, C. S., Sul, D., Lee, J., Bae, M., Hong, Y., Lee, M., Choi, S., Derby, R., Kim, B. J., Kim, J., Yoon, J. S., Wolfer, L., Kim, J., Wang, J., Hwang, S. W., & Lee, S. H. (2009). Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus. Clinical Biochemistry, 42(15), 1504-1511. https://doi.org/10.1016/j.clinbiochem.2009.06.017

Lee, S, Moon, CS, Sul, D, Lee, J, Bae, M, Hong, Y, Lee, M, Choi, S, Derby, R, Kim, BJ, Kim, J, Yoon, JS, Wolfer, L, Kim, J, Wang, J, Hwang, SW & Lee, SH 2009, 'Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus', Clinical Biochemistry, vol. 42, no. 15, pp. 1504-1511. https://doi.org/10.1016/j.clinbiochem.2009.06.017

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title = "Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus",

abstract = "Objectives: This study was conducted to investigate the expression of cytokines and growth factors in disc specimens obtained from patients with herniated nucleus pulposus (HNP) and degenerated disc disease (DDD). Design and methods: MRI and Western blot analyses were performed to evaluate the levels of disc degeneration and the expression levels of cytokines and growth factors. Results: The levels of TNF-α and IL-8 were significantly greater in the DDD group than in the HNP group, but no statistical differences were observed in the expression of IL-1β, IL-6 and IL-12 between the HNP and DDD groups. In addition, the expression of TGF β, VEGF and NGF was significantly higher in the DDD group than in the HNP group. Conclusion: The greater levels of cytokine and growth factor expression in the DDD group than in the HNP explain why discogenic patients usually have more severe back pain than patients with herniated discs.",

keywords = "Cytokines, Degenerated disc disease (DDD), Disc degeneration, Growth factors, Herniated nucleus pulposus (HNP), MRI",

author = "Seungcheol Lee and Moon, {Chan Sam} and Donggeun Sul and Jiyoung Lee and Minyoung Bae and Youngki Hong and Min Lee and Seonyoung Choi and Richard Derby and Kim, {Byung Jo} and Juhan Kim and Yoon, {Joon Sik} and Lee Wolfer and Jaemin Kim and Joonho Wang and Hwang, {Sun Wook} and Lee, {Sang Heon}",

note = "Funding Information: This study was supported by a grant from the Science Research Center/Engineering Research Center program of the Ministry of Science and Technology/Korea Science and Engineering Foundation (R11-2005-017-02002-0) and the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (0420160-1).",

year = "2009",

month = oct,

doi = "10.1016/j.clinbiochem.2009.06.017",

language = "English",

volume = "42",

pages = "1504--1511",

journal = "Clinical Biochemistry",

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T1 - Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus

AU - Lee, Seungcheol

AU - Moon, Chan Sam

AU - Sul, Donggeun

AU - Lee, Jiyoung

AU - Bae, Minyoung

AU - Hong, Youngki

AU - Lee, Min

AU - Choi, Seonyoung

AU - Derby, Richard

AU - Kim, Byung Jo

AU - Kim, Juhan

AU - Yoon, Joon Sik

AU - Wolfer, Lee

AU - Kim, Jaemin

AU - Wang, Joonho

AU - Hwang, Sun Wook

AU - Lee, Sang Heon

N1 - Funding Information: This study was supported by a grant from the Science Research Center/Engineering Research Center program of the Ministry of Science and Technology/Korea Science and Engineering Foundation (R11-2005-017-02002-0) and the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (0420160-1).

PY - 2009/10

Y1 - 2009/10

N2 - Objectives: This study was conducted to investigate the expression of cytokines and growth factors in disc specimens obtained from patients with herniated nucleus pulposus (HNP) and degenerated disc disease (DDD). Design and methods: MRI and Western blot analyses were performed to evaluate the levels of disc degeneration and the expression levels of cytokines and growth factors. Results: The levels of TNF-α and IL-8 were significantly greater in the DDD group than in the HNP group, but no statistical differences were observed in the expression of IL-1β, IL-6 and IL-12 between the HNP and DDD groups. In addition, the expression of TGF β, VEGF and NGF was significantly higher in the DDD group than in the HNP group. Conclusion: The greater levels of cytokine and growth factor expression in the DDD group than in the HNP explain why discogenic patients usually have more severe back pain than patients with herniated discs.

AB - Objectives: This study was conducted to investigate the expression of cytokines and growth factors in disc specimens obtained from patients with herniated nucleus pulposus (HNP) and degenerated disc disease (DDD). Design and methods: MRI and Western blot analyses were performed to evaluate the levels of disc degeneration and the expression levels of cytokines and growth factors. Results: The levels of TNF-α and IL-8 were significantly greater in the DDD group than in the HNP group, but no statistical differences were observed in the expression of IL-1β, IL-6 and IL-12 between the HNP and DDD groups. In addition, the expression of TGF β, VEGF and NGF was significantly higher in the DDD group than in the HNP group. Conclusion: The greater levels of cytokine and growth factor expression in the DDD group than in the HNP explain why discogenic patients usually have more severe back pain than patients with herniated discs.

KW - Cytokines

KW - Degenerated disc disease (DDD)

KW - Disc degeneration

KW - Growth factors

KW - Herniated nucleus pulposus (HNP)

KW - MRI

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JO - Clinical Biochemistry

JF - Clinical Biochemistry

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ER -

Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus

Abstract

Keywords

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