Comparison of magnetic properties of DNA-cetyltrimethyl ammonium complex with those of natural DNA

Young Wan Kwon; Dong Hoon Choi; Jung Il Jin; Chang Hoon Lee; Eui Kwan Koh; James G. Grote

doi:10.1007/s11426-012-4507-z

Comparison of magnetic properties of DNA-cetyltrimethyl ammonium complex with those of natural DNA

Young Wan Kwon, Dong Hoon Choi, Jung Il Jin, Chang Hoon Lee, Eui Kwan Koh, James G. Grote

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

We prepared the DNA-cetyltrimethyl ammonium complex, as well as the same complex intercalated with stable organic free radicals, and studied their magnetic properties by electron magnetic resonance (EMR) spectroscopy and by measuring the magnetization on a superconducting quantum interference device (SQUID). The UV-vis and CD spectra of DNA-quaternary alkyl ammonium complex (DNA ^--Q ⁺) in organic solvent clearly demonstrated that it retained the double helical B-form conformation. The interhelical spacing of double strand DNA (dsDNA) increased when the counter ions (Na ⁺) of phosphate groups of the natural DNA were replaced with the long alkyl quaternary ammonium groups. The inter-helical distance of DNA-cetyltrimethyl ammonium (CTMA) was 39.1 Å as confirmed by X-ray diffractometry. In general, the magnetization of the DNA-CTMA complex solid was found to be significantly lower than that of natural DNA. Moreover, intercalation of the complex with stable organic free radicals did not improve magnetization, which again was in marked contrast to natural DNA. EMR spectroscopic behavior of the complex in the solid state also was quite different from that of natural DNA: The unique broad EMR signal of natural DNA in the low field region with g-value greater than 10 disappeared in the DNA-CTMA complex.

Original language	English
Pages (from-to)	814-821
Number of pages	8
Journal	Science China Chemistry
Volume	55
Issue number	5
DOIs	https://doi.org/10.1007/s11426-012-4507-z
Publication status	Published - 2012 May

Bibliographical note

Funding Information:
This article is based on the report “Electromagnetic Properties of Modified DNA” (AOARD-074023) submitted by J. –I. Jin to the Asian Office of Aerospace R&D of the U.S.A. and KICOS of the Republic of Korea (K2071600003-07A0400-00310). Young-Wan Kwon would like to express his gratitude to the Korean National Foundation for the support (2010-0013225).

Keywords

DNA-CTMA
DNA-CTMA-PTMI
electron magnetic resonance (EMR)
magnetic property
natural DNA
superconducting quantum interference device (SQUID)

ASJC Scopus subject areas

General Chemistry

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10.1007/s11426-012-4507-z

Cite this

@article{d0e571c2baa74409a9f10444fc325e07,

title = "Comparison of magnetic properties of DNA-cetyltrimethyl ammonium complex with those of natural DNA",

abstract = "We prepared the DNA-cetyltrimethyl ammonium complex, as well as the same complex intercalated with stable organic free radicals, and studied their magnetic properties by electron magnetic resonance (EMR) spectroscopy and by measuring the magnetization on a superconducting quantum interference device (SQUID). The UV-vis and CD spectra of DNA-quaternary alkyl ammonium complex (DNA --Q +) in organic solvent clearly demonstrated that it retained the double helical B-form conformation. The interhelical spacing of double strand DNA (dsDNA) increased when the counter ions (Na +) of phosphate groups of the natural DNA were replaced with the long alkyl quaternary ammonium groups. The inter-helical distance of DNA-cetyltrimethyl ammonium (CTMA) was 39.1 {\AA} as confirmed by X-ray diffractometry. In general, the magnetization of the DNA-CTMA complex solid was found to be significantly lower than that of natural DNA. Moreover, intercalation of the complex with stable organic free radicals did not improve magnetization, which again was in marked contrast to natural DNA. EMR spectroscopic behavior of the complex in the solid state also was quite different from that of natural DNA: The unique broad EMR signal of natural DNA in the low field region with g-value greater than 10 disappeared in the DNA-CTMA complex.",

keywords = "DNA-CTMA, DNA-CTMA-PTMI, electron magnetic resonance (EMR), magnetic property, natural DNA, superconducting quantum interference device (SQUID)",

author = "Kwon, {Young Wan} and Choi, {Dong Hoon} and Jin, {Jung Il} and Lee, {Chang Hoon} and Koh, {Eui Kwan} and Grote, {James G.}",

note = "Funding Information: This article is based on the report “Electromagnetic Properties of Modified DNA” (AOARD-074023) submitted by J. –I. Jin to the Asian Office of Aerospace R&D of the U.S.A. and KICOS of the Republic of Korea (K2071600003-07A0400-00310). Young-Wan Kwon would like to express his gratitude to the Korean National Foundation for the support (2010-0013225).",

year = "2012",

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doi = "10.1007/s11426-012-4507-z",

language = "English",

volume = "55",

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T1 - Comparison of magnetic properties of DNA-cetyltrimethyl ammonium complex with those of natural DNA

AU - Kwon, Young Wan

AU - Choi, Dong Hoon

AU - Jin, Jung Il

AU - Lee, Chang Hoon

AU - Koh, Eui Kwan

AU - Grote, James G.

N1 - Funding Information: This article is based on the report “Electromagnetic Properties of Modified DNA” (AOARD-074023) submitted by J. –I. Jin to the Asian Office of Aerospace R&D of the U.S.A. and KICOS of the Republic of Korea (K2071600003-07A0400-00310). Young-Wan Kwon would like to express his gratitude to the Korean National Foundation for the support (2010-0013225).

PY - 2012/5

Y1 - 2012/5

N2 - We prepared the DNA-cetyltrimethyl ammonium complex, as well as the same complex intercalated with stable organic free radicals, and studied their magnetic properties by electron magnetic resonance (EMR) spectroscopy and by measuring the magnetization on a superconducting quantum interference device (SQUID). The UV-vis and CD spectra of DNA-quaternary alkyl ammonium complex (DNA --Q +) in organic solvent clearly demonstrated that it retained the double helical B-form conformation. The interhelical spacing of double strand DNA (dsDNA) increased when the counter ions (Na +) of phosphate groups of the natural DNA were replaced with the long alkyl quaternary ammonium groups. The inter-helical distance of DNA-cetyltrimethyl ammonium (CTMA) was 39.1 Å as confirmed by X-ray diffractometry. In general, the magnetization of the DNA-CTMA complex solid was found to be significantly lower than that of natural DNA. Moreover, intercalation of the complex with stable organic free radicals did not improve magnetization, which again was in marked contrast to natural DNA. EMR spectroscopic behavior of the complex in the solid state also was quite different from that of natural DNA: The unique broad EMR signal of natural DNA in the low field region with g-value greater than 10 disappeared in the DNA-CTMA complex.

AB - We prepared the DNA-cetyltrimethyl ammonium complex, as well as the same complex intercalated with stable organic free radicals, and studied their magnetic properties by electron magnetic resonance (EMR) spectroscopy and by measuring the magnetization on a superconducting quantum interference device (SQUID). The UV-vis and CD spectra of DNA-quaternary alkyl ammonium complex (DNA --Q +) in organic solvent clearly demonstrated that it retained the double helical B-form conformation. The interhelical spacing of double strand DNA (dsDNA) increased when the counter ions (Na +) of phosphate groups of the natural DNA were replaced with the long alkyl quaternary ammonium groups. The inter-helical distance of DNA-cetyltrimethyl ammonium (CTMA) was 39.1 Å as confirmed by X-ray diffractometry. In general, the magnetization of the DNA-CTMA complex solid was found to be significantly lower than that of natural DNA. Moreover, intercalation of the complex with stable organic free radicals did not improve magnetization, which again was in marked contrast to natural DNA. EMR spectroscopic behavior of the complex in the solid state also was quite different from that of natural DNA: The unique broad EMR signal of natural DNA in the low field region with g-value greater than 10 disappeared in the DNA-CTMA complex.

KW - DNA-CTMA

KW - DNA-CTMA-PTMI

KW - electron magnetic resonance (EMR)

KW - magnetic property

KW - natural DNA

KW - superconducting quantum interference device (SQUID)

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DO - 10.1007/s11426-012-4507-z

M3 - Article

AN - SCOPUS:84862797128

SN - 1674-7291

VL - 55

SP - 814

EP - 821

JO - Science China Chemistry

JF - Science China Chemistry

IS - 5

ER -

Comparison of magnetic properties of DNA-cetyltrimethyl ammonium complex with those of natural DNA

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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