Comparison of subchronic immunotoxicity of four different types of aluminum-based nanoparticles

Eun Jung Park, Sang Jin Lee, Gwang Hee Lee, Dong Wan Kim, Cheolho Yoon, Byoung Seok Lee, Younghun Kim, Jaerak Chang, Kyuhong Lee

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Nanoparticles (NPs) have recently emerged as an inhalable pollutant, owing to their applications, aluminum-based NPs (Al-NPs) have been prioritized for toxicity testing. In the current study, we compared the pulmonary biopersistence and subsequent toxicity of four different types of Al-NPs (two rod-type aluminum oxide NPs [AlONPs] with different aspect ratios [short (S)- and long (L)-AlONPs], spherical aluminum cerium oxide NPs [AlCeO 3 , AlCeONPs] and spherical γ-aluminum oxide hydroxide nanoparticles [AlOOHNPs]) 13weeks after a single intratracheal instillation, considering the importance of their properties in their toxicity. We found that the pulmonary biopersistence of Al-NPs was strengthened by a high aspect ratio in the rod-type AlONPs and by the presence of hydroxyl groups in the spherical-type Al-NPs. The highest toxicity was observed in the mice treated with AlOOHNPs, which showed low biostability. More importantly, we identified that the commercially available AlCeONPs were Al 2 O 3 -coated CeO 2 NPs, but not AlCeO 3 NPs, although they have been sold under the trade name of AlCeONPs. In conclusion, the aspect ratio and biostability may be important factors in the determination of the biopersistence of NPs and the subsequent biological response. In addition, the physicochemical properties of NPs should be examined in detail before their release into the market to prevent unexpected adverse health effects.

Original languageEnglish
Pages (from-to)575-584
Number of pages10
JournalJournal of Applied Toxicology
Issue number4
Publication statusPublished - 2018 Apr

Bibliographical note

Funding Information:
This work was supported by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology (2011‐35B‐E00011), and funded by Korea Institute of Toxicology (KIT) (Development of toxic substance prevention technology (KK‐1707)).

Funding Information:
Korea Institute of Toxicology, Grant/Award Number: KK‐1707; Ministry of Education, Science and Technology, Grant/Award Number: 2011‐35B‐E00011; Basic Science Research Program

Publisher Copyright:
Copyright © 2017 John Wiley & Sons, Ltd.


  • aluminum oxide nanoparticles
  • biopersistence
  • cerium oxide nanoparticles
  • inflammation
  • physicochemical properties

ASJC Scopus subject areas

  • Toxicology


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