Comparisonof the pathogenesis of SARS-CoV-2 infection inK18-hACE2 miceand Syrian golden hamstermodels

Haengdueng Jeong, Youn Woo Lee, In Ho Park, Hyuna Noh, Sung Hee Kim, Jiseon Kim, Donghun Jeon, Hui Jeong Jang, Jooyeon Oh, Dain On, Chanyang Uhm, Kyungrae Cho, Heeju Oh, Suhyeon Yoon, Jung Seon Seo, Jeong Jin Kim, Sang Hyuk Seok, Yu Jin Lee, Seung Min Hong, Se Hee AnSeo Yeon Kim, Young Been Kim, Ji Yeon Hwang, Hyo Jung Lee, Hong Bin Kim, Dae Gwin Jeong, Daesub Song, Manki Song, Man Seong Park, Kang Seuk Choi, Jun Won Park, Jun Young Seo, Jun Won Yun, Jeon Soo Shin, Ho Young Lee, Ki Taek Nam, Je Kyung Seong

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

SARS-CoV-2, the etiological agentofCOVID-19, causeslife-threatening disease. This novel coronavirusenters host cellsvia the respiratory tract,promoting the formation ofsevere pulmonary lesions andsystemic disease. Few animal models can simulate the clinical signs and pathology ofCOVID-19patients.Diverse preclinical studies using K18-hACE2 mice and Syrian golden hamsters, which are highly permissive toSARS-CoV-2 in therespiratory tract, are emerging; however, the systemic pathogenesis and cellular tropism of these models remain obscure. We intranasally infected K18-hACE2 mice and Syrian golden hamsterswith SARS-CoV-2, and compared the clinical features, pathogenesis, cellular tropism,and infiltrated immune-cellsubsets. In K18-hACE2 mice, SARS-CoV-2 persistently replicated inalveolar cells and causedpulmonary and extra-pulmonary disease, resulting in fataloutcomes. Conversely, in Syrian golden hamsters, transient SARS-CoV-2infectioninbronchial cells causedreversible pulmonary disease,without mortality. Our findings provide comprehensive insightsinto thepathogenic spectrum of COVID-19 using pre-clinical models.

Original languageEnglish
JournalDMM Disease Models and Mechanisms
Volume15
Issue number11
DOIs
Publication statusPublished - 2022 Nov

Bibliographical note

Publisher Copyright:
© 2022. Published by The Company of Biologists Ltd.

Keywords

  • K18-hACE2mice
  • SARS-CoV-2
  • Syriangoldenhamster

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Medicine (miscellaneous)
  • Immunology and Microbiology (miscellaneous)
  • General Biochemistry,Genetics and Molecular Biology

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