Comparisons of everolimus and paclitaxel-eluting stents in patients with acute myocardial infarction

Kang Yin Chen, Seung Woon Rha, Yong Jian Li, Guang Ping Li, Dong Joo Oh, Myung Ho Jeong, Young Jo Kim, Seung Ho Hur, Jang Ho Bae, Tae Hoon Ahn

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    3 Citations (Scopus)

    Abstract

    Background It has been established that the newer-generation drug-eluting stent (DES) everolimus-eluting stent (EES) is superior to the first-generation DES paclitaxel-eluting stent (PES). However, the advantages of EES over PES in the setting of acute myocardial infarction (AMI) need to be fully elucidated. Methods The present analysis enrolled 2,911 AMI patients receiving PES (n = 1,210) or EES (n = 1,701) in a large-scale, prospective, multicenter Korea Acute Myocardial Infarction Registry (KAMIR). Propensity score matching was used to adjust for baseline biases in clinical and angiographic characteristics, yielding a total of 2,398 patients (1,199 receiving PES and 1,199 receiving EES). Various clinical outcomes at 1 year were compared between the two propensity score matched groups. Target lesion failure (TLF) was defined as the composite of cardiac death, recurrent nonfatal myocardial infarction (Re-MI), or target lesion revascularization (TLR). Results Baseline clinical and angiographic characteristics were comparable between the two groups after propensity score matching. Clinical outcomes of the propensity score matched patients showed that the rates of in-hospital and 1-year cardiac and all-cause death were similar between the two groups. But patients in the EES group had significantly lower incidences of Re-MI (1.4% vs 2.8%, P = 0.002), TLR (1.2% vs 3.1%, P = 0.001), TLF (6.4% vs 10.2%, P = 0.001), and probable or definite stent thrombosis (0.3% vs 1.8%, P < 0.001) than did those in the PES group. Conclusions The present propensity matched analysis suggests that the use of EES in the setting of AMI appears to be superior to PES in reducing TLF, and stent thrombosis.

    Original languageEnglish
    Pages (from-to)147-156
    Number of pages10
    JournalJournal of Interventional Cardiology
    Volume28
    Issue number2
    DOIs
    Publication statusPublished - 2015 Apr 1

    Bibliographical note

    Publisher Copyright:
    © 2015, Wiley Periodicals, Inc.

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging
    • Cardiology and Cardiovascular Medicine

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