Competing patterns of signaling activity in dictyostelium discoideum

Kyoung J. Lee, Edward C. Cox, Raymond E. Goldstein

Research output: Contribution to journalArticlepeer-review

197 Citations (Scopus)


Quantitative experiments are described on spatiotemporal patterns of coherent chemical signaling activity in populations of Dictyostelium discoideum amoebae. We observe competition between spontaneously firing centers and rotating spiral waves that depends strongly on the overall cell density. At low densities, no complete spirals appear and chemotactic aggregation is driven by periodic concentric waves, whereas at high densities the firing centers seen at early times nucleate and are apparently entrained by spiral waves whose cores ultimately serve as aggregation centers. Possible mechanisms for these observations are discussed.

Original languageEnglish
Pages (from-to)1174-1177
Number of pages4
JournalPhysical review letters
Issue number7
Publication statusPublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • General Physics and Astronomy


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