Complete Genome Sequence and Phylogenetic Analysis of Hepatitis B Virus (HBV) Isolates From Patients With Chronic HBV Infection in Korea

Zagaa Odgerel; Kyung Bo Nho; Ju Young Moon; Sun Ho Kee; Kwang Sook Park; Ki Joon Song; Luck Ju Baek; Jong Eun Yeon; Kwan Soo Byun; Chang Hong Lee; Jin Won Song

doi:10.1002/jmv.10506

Complete Genome Sequence and Phylogenetic Analysis of Hepatitis B Virus (HBV) Isolates From Patients With Chronic HBV Infection in Korea

Zagaa Odgerel, Kyung Bo Nho, Ju Young Moon, Sun Ho Kee, Kwang Sook Park, Ki Joon Song, Luck Ju Baek, Jong Eun Yeon, Kwan Soo Byun, Chang Hong Lee, Jin Won Song

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Although there is a report of high rate of hepatitis B virus (HBV) infection in South Korea, only a few entire genome sequences of HBV isolates from Korea have been reported. To obtain the complete nucleotide sequence of the Korean HBV, viral DNA was extracted from sera of Korean patients with chronic HBV infection who have not been exposed to any antiviral treatment. Complete genomic sequences were determined on three Korean HBV isolates. The entire genomic length of Korean HBV isolates, designated as KUHB84, KUHB81, and KUHB95, was 3,215 base pairs. No deletions and insertions were observed. Core promoter mutations (T1762/A1764) were detected in two isolates, KUHB84 and KUHB95. Phylogenetic analysis based on the entire genomic sequences showed that the Korean HBV isolates were genotype C and related closely to the Japanese HBV.

Original language	English
Pages (from-to)	499-503
Number of pages	5
Journal	Journal of Medical Virology
Volume	71
Issue number	4
DOIs	https://doi.org/10.1002/jmv.10506
Publication status	Published - 2003 Dec

Keywords

Chronic hepatitis
HBV genotype
Phylogeny
Polymerase chain reaction

ASJC Scopus subject areas

Infectious Diseases
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jmv.10506

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title = "Complete Genome Sequence and Phylogenetic Analysis of Hepatitis B Virus (HBV) Isolates From Patients With Chronic HBV Infection in Korea",

abstract = "Although there is a report of high rate of hepatitis B virus (HBV) infection in South Korea, only a few entire genome sequences of HBV isolates from Korea have been reported. To obtain the complete nucleotide sequence of the Korean HBV, viral DNA was extracted from sera of Korean patients with chronic HBV infection who have not been exposed to any antiviral treatment. Complete genomic sequences were determined on three Korean HBV isolates. The entire genomic length of Korean HBV isolates, designated as KUHB84, KUHB81, and KUHB95, was 3,215 base pairs. No deletions and insertions were observed. Core promoter mutations (T1762/A1764) were detected in two isolates, KUHB84 and KUHB95. Phylogenetic analysis based on the entire genomic sequences showed that the Korean HBV isolates were genotype C and related closely to the Japanese HBV.",

keywords = "Chronic hepatitis, HBV genotype, Phylogeny, Polymerase chain reaction",

author = "Zagaa Odgerel and Nho, {Kyung Bo} and Moon, {Ju Young} and Kee, {Sun Ho} and Park, {Kwang Sook} and Song, {Ki Joon} and Baek, {Luck Ju} and Yeon, {Jong Eun} and Byun, {Kwan Soo} and Lee, {Chang Hong} and Song, {Jin Won}",

year = "2003",

month = dec,

doi = "10.1002/jmv.10506",

language = "English",

volume = "71",

pages = "499--503",

journal = "Journal of Medical Virology",

issn = "0146-6615",

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T1 - Complete Genome Sequence and Phylogenetic Analysis of Hepatitis B Virus (HBV) Isolates From Patients With Chronic HBV Infection in Korea

AU - Odgerel, Zagaa

AU - Nho, Kyung Bo

AU - Moon, Ju Young

AU - Kee, Sun Ho

AU - Park, Kwang Sook

AU - Song, Ki Joon

AU - Baek, Luck Ju

AU - Yeon, Jong Eun

AU - Byun, Kwan Soo

AU - Lee, Chang Hong

AU - Song, Jin Won

PY - 2003/12

Y1 - 2003/12

N2 - Although there is a report of high rate of hepatitis B virus (HBV) infection in South Korea, only a few entire genome sequences of HBV isolates from Korea have been reported. To obtain the complete nucleotide sequence of the Korean HBV, viral DNA was extracted from sera of Korean patients with chronic HBV infection who have not been exposed to any antiviral treatment. Complete genomic sequences were determined on three Korean HBV isolates. The entire genomic length of Korean HBV isolates, designated as KUHB84, KUHB81, and KUHB95, was 3,215 base pairs. No deletions and insertions were observed. Core promoter mutations (T1762/A1764) were detected in two isolates, KUHB84 and KUHB95. Phylogenetic analysis based on the entire genomic sequences showed that the Korean HBV isolates were genotype C and related closely to the Japanese HBV.

AB - Although there is a report of high rate of hepatitis B virus (HBV) infection in South Korea, only a few entire genome sequences of HBV isolates from Korea have been reported. To obtain the complete nucleotide sequence of the Korean HBV, viral DNA was extracted from sera of Korean patients with chronic HBV infection who have not been exposed to any antiviral treatment. Complete genomic sequences were determined on three Korean HBV isolates. The entire genomic length of Korean HBV isolates, designated as KUHB84, KUHB81, and KUHB95, was 3,215 base pairs. No deletions and insertions were observed. Core promoter mutations (T1762/A1764) were detected in two isolates, KUHB84 and KUHB95. Phylogenetic analysis based on the entire genomic sequences showed that the Korean HBV isolates were genotype C and related closely to the Japanese HBV.

KW - Chronic hepatitis

KW - HBV genotype

KW - Phylogeny

KW - Polymerase chain reaction

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U2 - 10.1002/jmv.10506

DO - 10.1002/jmv.10506

M3 - Article

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AN - SCOPUS:10744225305

SN - 0146-6615

VL - 71

SP - 499

EP - 503

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 4

ER -

Complete Genome Sequence and Phylogenetic Analysis of Hepatitis B Virus (HBV) Isolates From Patients With Chronic HBV Infection in Korea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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