Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction

Yong Un Kang; Min Jee Kim; Joon Seok Choi; Chang Seong Kim; Eun Hui Bae; Seong Kwon Ma; Young Keun Ahn; Myung Ho Jeong; Young Jo Kim; Myeong Chan Cho; Chong Jin Kim; Soo Wan Kim; Myung Ho Jeong; Young Keun Ahn; Sung Chull Chae; Jong Hyun Kim; Seung Ho Hur; Young Jo Kim; In Whan Seong; Dong Hoon Choi; Jei Keon Chae; Taek Jong Hong; Jae Young Rhew; Doo Il Kim; In Ho Chae; Jung Han Yoon; Bon Kwon Koo; Byung Ok Kim; Myoung Yong Lee; Kee Sik Kim; Jin Yong Hwang; Seok Kyu Oh; Nae Hee Lee; Kyoung Tae Jeong; Seung Jea Tahk; Jang Ho Bae; Seung Woon Rha; Keum Soo Park; Kyoo Rok Han; Tae Hoon Ahn; Moo Hyun Kim; Ki Bae Seung; Wook Sung Chung; Ju Young Yang; Chong Yun Rhim; Hyeon Cheol Gwon; Seong Wook Park; Young Youp Koh; Seung Jae Joo; Soo Joong Kim; Dong Kyu Jin; Jin Man Cho; Byung Ok Kim; Sang Wook Kim; Jeong Kyung Kim; Tae Ik Kim; Deug Young Nah; Si Hoon Park; Sang Hyun Lee; Seung Uk Lee; Hang Jae Chung; Jang Hyun Cho; Seung Won Jin; Yang Soo Jang; Jeong Gwan Cho; Seung Jung Park

doi:10.3349/ymj.2014.55.1.132

Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction

Yong Un Kang, Min Jee Kim, Joon Seok Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Young Keun Ahn, Myung Ho Jeong, Young Jo Kim, Myeong Chan Cho, Chong Jin Kim, Soo Wan Kim, Myung Ho Jeong, Young Keun Ahn, Sung Chull Chae, Jong Hyun Kim, Seung Ho Hur, Young Jo Kim, In Whan Seong, Dong Hoon ChoiJei Keon Chae, Taek Jong Hong, Jae Young Rhew, Doo Il Kim, In Ho Chae, Jung Han Yoon, Bon Kwon Koo, Byung Ok Kim, Myoung Yong Lee, Kee Sik Kim, Jin Yong Hwang, Seok Kyu Oh, Nae Hee Lee, Kyoung Tae Jeong, Seung Jea Tahk, Jang Ho Bae, Seung Woon Rha, Keum Soo Park, Kyoo Rok Han, Tae Hoon Ahn, Moo Hyun Kim, Ki Bae Seung, Wook Sung Chung, Ju Young Yang, Chong Yun Rhim, Hyeon Cheol Gwon, Seong Wook Park, Young Youp Koh, Seung Jae Joo, Soo Joong Kim, Dong Kyu Jin, Jin Man Cho, Byung Ok Kim, Sang Wook Kim, Jeong Kyung Kim, Tae Ik Kim, Deug Young Nah, Si Hoon Park, Sang Hyun Lee, Seung Uk Lee, Hang Jae Chung, Jang Hyun Cho, Seung Won Jin, Yang Soo Jang, Jeong Gwan Cho, Seung Jung Park

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Purpose: The present study aimed to investigate the impact of high-sensitivity C-reactive protein (hs-CRP) and renal dysfunction on clinical outcomes in acute myocardial infarction (AMI) patients. Materials and Methods: The study involved a retrospective cohort of 8332 patients admitted with AMI. The participants were divided into 4 groups according to the levels of estimated glomerular filtration rate (eGFR) and hs-CRP: group I, no renal dysfunction (eGFR ≥60 mL·min^-1·1.73 m^-2) with low hs-CRP (≤2.0 mg/dL); group II, no renal dysfunction with high hs-CRP; group III, renal dysfunction with low hs-CRP; and group IV, renal dysfunction with high hs-CRP. We compared major adverse cardiac events (MACE) over a 1-year follow-up period. Results: The 4 groups demonstrated a graded association with increased MACE rates (group I, 8.8%; group II, 13.8%; group III, 18.6%; group IV, 30.1%; p<0.001). In a Cox proportional hazards model, mortality at 12 months increased in groups II, III, and IV compared with group I [hazard ratio (HR) 2.038, 95% confidence interval (CI) 1.450-2.863, p<0.001; HR 3.003, 95% CI 2.269-3.974, p<0.001; HR 5.087, 95% CI 3.755-6.891, p<0.001]. Conclusion: High hs-CRP, especially in association with renal dysfunction, is related to the occurrence of composite MACE, and indicates poor prognosis in AMI patients.

Original language	English
Pages (from-to)	132-140
Number of pages	9
Journal	Yonsei medical journal
Volume	55
Issue number	1
DOIs	https://doi.org/10.3349/ymj.2014.55.1.132
Publication status	Published - 2014 Jan 1

Keywords

C-reactive protein
Glomerular filtration rate
Myocardial infarction

ASJC Scopus subject areas

Medicine(all)

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10.3349/ymj.2014.55.1.132

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Kang, Y. U., Kim, M. J., Choi, J. S., Kim, C. S., Bae, E. H., Ma, S. K., Ahn, Y. K., Jeong, M. H., Kim, Y. J., Cho, M. C., Kim, C. J., Kim, S. W., Jeong, M. H., Ahn, Y. K., Chae, S. C., Kim, J. H., Hur, S. H., Kim, Y. J., Seong, I. W., ... Park, S. J. (2014). Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction. Yonsei medical journal, 55(1), 132-140. https://doi.org/10.3349/ymj.2014.55.1.132

Kang, YU, Kim, MJ, Choi, JS, Kim, CS, Bae, EH, Ma, SK, Ahn, YK, Jeong, MH, Kim, YJ, Cho, MC, Kim, CJ, Kim, SW, Jeong, MH, Ahn, YK, Chae, SC, Kim, JH, Hur, SH, Kim, YJ, Seong, IW, Choi, DH, Chae, JK, Hong, TJ, Rhew, JY, Kim, DI, Chae, IH, Yoon, JH, Koo, BK, Kim, BO, Lee, MY, Kim, KS, Hwang, JY, Oh, SK, Lee, NH, Jeong, KT, Tahk, SJ, Bae, JH, Rha, SW, Park, KS, Han, KR, Ahn, TH, Kim, MH, Seung, KB, Chung, WS, Yang, JY, Rhim, CY, Gwon, HC, Park, SW, Koh, YY, Joo, SJ, Kim, SJ, Jin, DK, Cho, JM, Kim, BO, Kim, SW, Kim, JK, Kim, TI, Nah, DY, Park, SH, Lee, SH, Lee, SU, Chung, HJ, Cho, JH, Jin, SW, Jang, YS, Cho, JG & Park, SJ 2014, 'Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction', Yonsei medical journal, vol. 55, no. 1, pp. 132-140. https://doi.org/10.3349/ymj.2014.55.1.132

@article{7b7e5d68bc7543caae639fc6b966b1b8,

title = "Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction",

abstract = "Purpose: The present study aimed to investigate the impact of high-sensitivity C-reactive protein (hs-CRP) and renal dysfunction on clinical outcomes in acute myocardial infarction (AMI) patients. Materials and Methods: The study involved a retrospective cohort of 8332 patients admitted with AMI. The participants were divided into 4 groups according to the levels of estimated glomerular filtration rate (eGFR) and hs-CRP: group I, no renal dysfunction (eGFR ≥60 mL·min-1·1.73 m-2) with low hs-CRP (≤2.0 mg/dL); group II, no renal dysfunction with high hs-CRP; group III, renal dysfunction with low hs-CRP; and group IV, renal dysfunction with high hs-CRP. We compared major adverse cardiac events (MACE) over a 1-year follow-up period. Results: The 4 groups demonstrated a graded association with increased MACE rates (group I, 8.8%; group II, 13.8%; group III, 18.6%; group IV, 30.1%; p<0.001). In a Cox proportional hazards model, mortality at 12 months increased in groups II, III, and IV compared with group I [hazard ratio (HR) 2.038, 95% confidence interval (CI) 1.450-2.863, p<0.001; HR 3.003, 95% CI 2.269-3.974, p<0.001; HR 5.087, 95% CI 3.755-6.891, p<0.001]. Conclusion: High hs-CRP, especially in association with renal dysfunction, is related to the occurrence of composite MACE, and indicates poor prognosis in AMI patients.",

keywords = "C-reactive protein, Glomerular filtration rate, Myocardial infarction",

author = "Kang, {Yong Un} and Kim, {Min Jee} and Choi, {Joon Seok} and Kim, {Chang Seong} and Bae, {Eun Hui} and Ma, {Seong Kwon} and Ahn, {Young Keun} and Jeong, {Myung Ho} and Kim, {Young Jo} and Cho, {Myeong Chan} and Kim, {Chong Jin} and Kim, {Soo Wan} and Jeong, {Myung Ho} and Ahn, {Young Keun} and Chae, {Sung Chull} and Kim, {Jong Hyun} and Hur, {Seung Ho} and Kim, {Young Jo} and Seong, {In Whan} and Choi, {Dong Hoon} and Chae, {Jei Keon} and Hong, {Taek Jong} and Rhew, {Jae Young} and Kim, {Doo Il} and Chae, {In Ho} and Yoon, {Jung Han} and Koo, {Bon Kwon} and Kim, {Byung Ok} and Lee, {Myoung Yong} and Kim, {Kee Sik} and Hwang, {Jin Yong} and Oh, {Seok Kyu} and Lee, {Nae Hee} and Jeong, {Kyoung Tae} and Tahk, {Seung Jea} and Bae, {Jang Ho} and Rha, {Seung Woon} and Park, {Keum Soo} and Han, {Kyoo Rok} and Ahn, {Tae Hoon} and Kim, {Moo Hyun} and Seung, {Ki Bae} and Chung, {Wook Sung} and Yang, {Ju Young} and Rhim, {Chong Yun} and Gwon, {Hyeon Cheol} and Park, {Seong Wook} and Koh, {Young Youp} and Joo, {Seung Jae} and Kim, {Soo Joong} and Jin, {Dong Kyu} and Cho, {Jin Man} and Kim, {Byung Ok} and Kim, {Sang Wook} and Kim, {Jeong Kyung} and Kim, {Tae Ik} and Nah, {Deug Young} and Park, {Si Hoon} and Lee, {Sang Hyun} and Lee, {Seung Uk} and Chung, {Hang Jae} and Cho, {Jang Hyun} and Jin, {Seung Won} and Jang, {Yang Soo} and Cho, {Jeong Gwan} and Park, {Seung Jung}",

year = "2014",

month = jan,

day = "1",

doi = "10.3349/ymj.2014.55.1.132",

language = "English",

volume = "55",

pages = "132--140",

journal = "Yonsei Medical Journal",

issn = "0513-5796",

publisher = "Yonsei University College of Medicine",

number = "1",

}

TY - JOUR

T1 - Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction

AU - Kang, Yong Un

AU - Kim, Min Jee

AU - Choi, Joon Seok

AU - Kim, Chang Seong

AU - Bae, Eun Hui

AU - Ma, Seong Kwon

AU - Ahn, Young Keun

AU - Jeong, Myung Ho

AU - Kim, Young Jo

AU - Cho, Myeong Chan

AU - Kim, Chong Jin

AU - Kim, Soo Wan

AU - Jeong, Myung Ho

AU - Ahn, Young Keun

AU - Chae, Sung Chull

AU - Kim, Jong Hyun

AU - Hur, Seung Ho

AU - Kim, Young Jo

AU - Seong, In Whan

AU - Choi, Dong Hoon

AU - Chae, Jei Keon

AU - Hong, Taek Jong

AU - Rhew, Jae Young

AU - Kim, Doo Il

AU - Chae, In Ho

AU - Yoon, Jung Han

AU - Koo, Bon Kwon

AU - Kim, Byung Ok

AU - Lee, Myoung Yong

AU - Kim, Kee Sik

AU - Hwang, Jin Yong

AU - Oh, Seok Kyu

AU - Lee, Nae Hee

AU - Jeong, Kyoung Tae

AU - Tahk, Seung Jea

AU - Bae, Jang Ho

AU - Rha, Seung Woon

AU - Park, Keum Soo

AU - Han, Kyoo Rok

AU - Ahn, Tae Hoon

AU - Kim, Moo Hyun

AU - Seung, Ki Bae

AU - Chung, Wook Sung

AU - Yang, Ju Young

AU - Rhim, Chong Yun

AU - Gwon, Hyeon Cheol

AU - Park, Seong Wook

AU - Koh, Young Youp

AU - Joo, Seung Jae

AU - Kim, Soo Joong

AU - Jin, Dong Kyu

AU - Cho, Jin Man

AU - Kim, Byung Ok

AU - Kim, Sang Wook

AU - Kim, Jeong Kyung

AU - Kim, Tae Ik

AU - Nah, Deug Young

AU - Park, Si Hoon

AU - Lee, Sang Hyun

AU - Lee, Seung Uk

AU - Chung, Hang Jae

AU - Cho, Jang Hyun

AU - Jin, Seung Won

AU - Jang, Yang Soo

AU - Cho, Jeong Gwan

AU - Park, Seung Jung

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose: The present study aimed to investigate the impact of high-sensitivity C-reactive protein (hs-CRP) and renal dysfunction on clinical outcomes in acute myocardial infarction (AMI) patients. Materials and Methods: The study involved a retrospective cohort of 8332 patients admitted with AMI. The participants were divided into 4 groups according to the levels of estimated glomerular filtration rate (eGFR) and hs-CRP: group I, no renal dysfunction (eGFR ≥60 mL·min-1·1.73 m-2) with low hs-CRP (≤2.0 mg/dL); group II, no renal dysfunction with high hs-CRP; group III, renal dysfunction with low hs-CRP; and group IV, renal dysfunction with high hs-CRP. We compared major adverse cardiac events (MACE) over a 1-year follow-up period. Results: The 4 groups demonstrated a graded association with increased MACE rates (group I, 8.8%; group II, 13.8%; group III, 18.6%; group IV, 30.1%; p<0.001). In a Cox proportional hazards model, mortality at 12 months increased in groups II, III, and IV compared with group I [hazard ratio (HR) 2.038, 95% confidence interval (CI) 1.450-2.863, p<0.001; HR 3.003, 95% CI 2.269-3.974, p<0.001; HR 5.087, 95% CI 3.755-6.891, p<0.001]. Conclusion: High hs-CRP, especially in association with renal dysfunction, is related to the occurrence of composite MACE, and indicates poor prognosis in AMI patients.

AB - Purpose: The present study aimed to investigate the impact of high-sensitivity C-reactive protein (hs-CRP) and renal dysfunction on clinical outcomes in acute myocardial infarction (AMI) patients. Materials and Methods: The study involved a retrospective cohort of 8332 patients admitted with AMI. The participants were divided into 4 groups according to the levels of estimated glomerular filtration rate (eGFR) and hs-CRP: group I, no renal dysfunction (eGFR ≥60 mL·min-1·1.73 m-2) with low hs-CRP (≤2.0 mg/dL); group II, no renal dysfunction with high hs-CRP; group III, renal dysfunction with low hs-CRP; and group IV, renal dysfunction with high hs-CRP. We compared major adverse cardiac events (MACE) over a 1-year follow-up period. Results: The 4 groups demonstrated a graded association with increased MACE rates (group I, 8.8%; group II, 13.8%; group III, 18.6%; group IV, 30.1%; p<0.001). In a Cox proportional hazards model, mortality at 12 months increased in groups II, III, and IV compared with group I [hazard ratio (HR) 2.038, 95% confidence interval (CI) 1.450-2.863, p<0.001; HR 3.003, 95% CI 2.269-3.974, p<0.001; HR 5.087, 95% CI 3.755-6.891, p<0.001]. Conclusion: High hs-CRP, especially in association with renal dysfunction, is related to the occurrence of composite MACE, and indicates poor prognosis in AMI patients.

KW - C-reactive protein

KW - Glomerular filtration rate

KW - Myocardial infarction

UR - http://www.scopus.com/inward/record.url?scp=84890767165&partnerID=8YFLogxK

U2 - 10.3349/ymj.2014.55.1.132

DO - 10.3349/ymj.2014.55.1.132

M3 - Article

C2 - 24339298

AN - SCOPUS:84890767165

SN - 0513-5796

VL - 55

SP - 132

EP - 140

JO - Yonsei Medical Journal

JF - Yonsei Medical Journal

IS - 1

ER -

Concomitant impact of high-sensitivity C-reactive protein and renal dysfunction in patients with acute myocardial infarction

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