TY - JOUR
T1 - Conductive polylactic-acid filament for dose monitoring in syringe-less wearable infusion pump
AU - Jeon, Sangbin
AU - Chua, Beelee
N1 - Funding Information:
This work was supported by National Research Foundation of Korea ( NRF-2015 R1D1A1A01060317 and NRF-2017 R1A2B4005133 ). The authors would like to thank Miri Park for the assistance with the SEM and Prof. Ahjeong Son at Ewha Womans University for the laboratory resources.
Publisher Copyright:
© 2017 Elsevier B.V.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - We have demonstrated the use of conductive polylactic acid (PLA) filament for dose monitoring in a syringe-less wearable infusion pump. A channel reservoir is inlaid with conductive PLA filament. As the liquid medium is dispensed via gas pressurization by an built-in electrolysis chamber, the effective impedance of the conductive PLA filament/liquid medium column changes as well. This allows the dispensed volume to be monitored via the output voltage across a series resistor. Using 5 V sinusoidal input voltage, the output voltage decreased from ∼1.3 to ∼0.13 V as the dispensed volume of 0.1 mol/L PBS increased from 0 to 1000 μL. Similarly, the output voltage for insulin analog decreased from ∼0.64 to 0.126 V for the same volume displaced. Repeated dispensing runs with 0.1 mol/L PBS showed good consistency (standard deviation less than 10 mV). The rate of change of the output voltage with elapsed time varied accordingly for the different flow rates (0.25–1.00 mL/h or ∼4–17 μL/min). At electrolysis voltages of 1.5 and 5 V, the respective output voltage were 1.04 and 0.33 V. These corresponded to flow rates of ∼3 and 10 mL/h (∼50 and 160 μL/ min).
AB - We have demonstrated the use of conductive polylactic acid (PLA) filament for dose monitoring in a syringe-less wearable infusion pump. A channel reservoir is inlaid with conductive PLA filament. As the liquid medium is dispensed via gas pressurization by an built-in electrolysis chamber, the effective impedance of the conductive PLA filament/liquid medium column changes as well. This allows the dispensed volume to be monitored via the output voltage across a series resistor. Using 5 V sinusoidal input voltage, the output voltage decreased from ∼1.3 to ∼0.13 V as the dispensed volume of 0.1 mol/L PBS increased from 0 to 1000 μL. Similarly, the output voltage for insulin analog decreased from ∼0.64 to 0.126 V for the same volume displaced. Repeated dispensing runs with 0.1 mol/L PBS showed good consistency (standard deviation less than 10 mV). The rate of change of the output voltage with elapsed time varied accordingly for the different flow rates (0.25–1.00 mL/h or ∼4–17 μL/min). At electrolysis voltages of 1.5 and 5 V, the respective output voltage were 1.04 and 0.33 V. These corresponded to flow rates of ∼3 and 10 mL/h (∼50 and 160 μL/ min).
KW - Dose monitoring
KW - Infusion pump
KW - Insulin analog
KW - PLA filament
KW - Wearable
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U2 - 10.1016/j.snb.2017.12.014
DO - 10.1016/j.snb.2017.12.014
M3 - Article
AN - SCOPUS:85037668175
SN - 0925-4005
VL - 258
SP - 1080
EP - 1089
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
ER -