Conserved sequences of thrombospondin-related adhesive protein gene of Plasmodium vivax in clinical isolates from Korea

Myung H. Nam; Jin W. Jang; Hanna Kim; Eun T. Han; Won J. Lee; Seong S.A. An; Ae S.D. Park; Chae S. Lim

doi:10.1111/j.1365-3156.2011.02784.x

Conserved sequences of thrombospondin-related adhesive protein gene of Plasmodium vivax in clinical isolates from Korea

Myung H. Nam, Jin W. Jang, Hanna Kim, Eun T. Han, Won J. Lee, Seong S.A. An, Ae S.D. Park, Chae S. Lim

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Thrombospondin-related adhesive protein (TRAP) from Plasmodium vivax (P. vivax) became one of the important vaccine candidates for malaria, because P. vivax TRAP (PvTRAP) is responsible for the sporozoite-host interactions. PvTRAP polymorphisms in the isolates from Republic of Korea (ROK) were analysed, setting the valuable baseline data for the future vaccine developments and clinical trials with PvTRAP, as a strong vaccine candidate. A total of 54 isolates were collected in 2010. PvTRAP genes from above isolates were amplified and sequenced, and the results were analysed and compared against Sal-1 strain. Sequencing analysis of 1424-bp-size PvTRAP PCR products revealed one major allelic type with six non-synonymous substitutions, where S81T, E95D, I121V and T127R substitutions were found in region II, and K371N and A425E substitutions from region IV. The ROK isolates revealed the limited sequence polymorphisms in PvTRAP in comparison with the reported isolates from other nations.

Original language	English
Pages (from-to)	923-928
Number of pages	6
Journal	Tropical Medicine and International Health
Volume	16
Issue number	8
DOIs	https://doi.org/10.1111/j.1365-3156.2011.02784.x
Publication status	Published - 2011 Aug

Keywords

Korea
Malaria vaccine
Plasmodium vivax
Polymorphism
Thrombospondin-related adhesive protein

ASJC Scopus subject areas

Parasitology
Public Health, Environmental and Occupational Health
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1365-3156.2011.02784.x

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title = "Conserved sequences of thrombospondin-related adhesive protein gene of Plasmodium vivax in clinical isolates from Korea",

abstract = "Thrombospondin-related adhesive protein (TRAP) from Plasmodium vivax (P. vivax) became one of the important vaccine candidates for malaria, because P. vivax TRAP (PvTRAP) is responsible for the sporozoite-host interactions. PvTRAP polymorphisms in the isolates from Republic of Korea (ROK) were analysed, setting the valuable baseline data for the future vaccine developments and clinical trials with PvTRAP, as a strong vaccine candidate. A total of 54 isolates were collected in 2010. PvTRAP genes from above isolates were amplified and sequenced, and the results were analysed and compared against Sal-1 strain. Sequencing analysis of 1424-bp-size PvTRAP PCR products revealed one major allelic type with six non-synonymous substitutions, where S81T, E95D, I121V and T127R substitutions were found in region II, and K371N and A425E substitutions from region IV. The ROK isolates revealed the limited sequence polymorphisms in PvTRAP in comparison with the reported isolates from other nations.",

keywords = "Korea, Malaria vaccine, Plasmodium vivax, Polymorphism, Thrombospondin-related adhesive protein",

author = "Nam, {Myung H.} and Jang, {Jin W.} and Hanna Kim and Han, {Eun T.} and Lee, {Won J.} and An, {Seong S.A.} and Park, {Ae S.D.} and Lim, {Chae S.}",

year = "2011",

month = aug,

doi = "10.1111/j.1365-3156.2011.02784.x",

language = "English",

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pages = "923--928",

journal = "Tropical Medicine and International Health",

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AU - Nam, Myung H.

AU - Jang, Jin W.

AU - Kim, Hanna

AU - Han, Eun T.

AU - Lee, Won J.

AU - An, Seong S.A.

AU - Park, Ae S.D.

AU - Lim, Chae S.

PY - 2011/8

Y1 - 2011/8

N2 - Thrombospondin-related adhesive protein (TRAP) from Plasmodium vivax (P. vivax) became one of the important vaccine candidates for malaria, because P. vivax TRAP (PvTRAP) is responsible for the sporozoite-host interactions. PvTRAP polymorphisms in the isolates from Republic of Korea (ROK) were analysed, setting the valuable baseline data for the future vaccine developments and clinical trials with PvTRAP, as a strong vaccine candidate. A total of 54 isolates were collected in 2010. PvTRAP genes from above isolates were amplified and sequenced, and the results were analysed and compared against Sal-1 strain. Sequencing analysis of 1424-bp-size PvTRAP PCR products revealed one major allelic type with six non-synonymous substitutions, where S81T, E95D, I121V and T127R substitutions were found in region II, and K371N and A425E substitutions from region IV. The ROK isolates revealed the limited sequence polymorphisms in PvTRAP in comparison with the reported isolates from other nations.

AB - Thrombospondin-related adhesive protein (TRAP) from Plasmodium vivax (P. vivax) became one of the important vaccine candidates for malaria, because P. vivax TRAP (PvTRAP) is responsible for the sporozoite-host interactions. PvTRAP polymorphisms in the isolates from Republic of Korea (ROK) were analysed, setting the valuable baseline data for the future vaccine developments and clinical trials with PvTRAP, as a strong vaccine candidate. A total of 54 isolates were collected in 2010. PvTRAP genes from above isolates were amplified and sequenced, and the results were analysed and compared against Sal-1 strain. Sequencing analysis of 1424-bp-size PvTRAP PCR products revealed one major allelic type with six non-synonymous substitutions, where S81T, E95D, I121V and T127R substitutions were found in region II, and K371N and A425E substitutions from region IV. The ROK isolates revealed the limited sequence polymorphisms in PvTRAP in comparison with the reported isolates from other nations.

KW - Korea

KW - Malaria vaccine

KW - Plasmodium vivax

KW - Polymorphism

KW - Thrombospondin-related adhesive protein

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Conserved sequences of thrombospondin-related adhesive protein gene of Plasmodium vivax in clinical isolates from Korea

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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