Constrained sparse functional connectivity networks for MCI classification

Chong Yaw Wee, Pew Thian Yap, Daoqiang Zhang, Lihong Wang, Dinggang Shen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

38 Citations (Scopus)


Mild cognitive impairment (MCI) is difficult to diagnose due to its subtlety. Recent emergence of advanced network analysis techniques utilizing resting-state functional Magnetic Resonance Imaging (rs-fMRI) has made the understanding of neurological disorders more comprehensively at a whole-brain connectivity level. However, inferring effective brain connectivity from fMRI data is a challenging task, particularly when the ultimate goal is to obtain good control-patient classification performance. Incorporating sparsity into connectivity modeling can potentially produce results that are biologically more meaningful since most biologically networks are formed by a relatively few number of connections. However, this constraint, when applied at an individual level, will degrade classification performance due to inter-subject variability. To address this problem, we consider a constrained sparse linear regression model associated with the least absolute shrinkage and selection operator (LASSO). Specifically, we introduced sparsity into brain connectivity via l1-norm penalization, and ensured consistent non-zero connections across subjects via l2-norm penalization. Our results demonstrate that the constrained sparse network gives better classification performance than the conventional correlation-based network, indicating its greater sensitivity to early stage brain pathologies.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer-Assisted Intervention - MICCAI2012 - 15th International Conference, Proceedings
EditorsBjoern H. Menze, Zhuowen Tu, Antonio Criminisi, Bjoern H. Menze, Georg Langs, Albert Montillo, Nicholas Ayache, Hervé Delingette, Le Lu, Georg Langs, Polina Golland, Kensaku Mori
PublisherSpringer Verlag
Number of pages8
Volume7511 LNCS
ISBN (Print)9783642334177
Publication statusPublished - 2012
Event15th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2012 - Nice, France
Duration: 2012 Oct 52012 Oct 5

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume7511 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


Conference15th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2012

Bibliographical note

Publisher Copyright:
© Springer-Verlag Berlin Heidelberg 2012.

ASJC Scopus subject areas

  • Theoretical Computer Science
  • General Computer Science


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